A trial looking at MK-3475A for certain types of lymphoma (MK-3475A-F65)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have classical Hodgkin lymphoma or primary mediastinal large B-cell lymphoma that has got worse or treatment had stopped working 
• have lymphoma that can be measured on a scan 
• have satisfactory blood test results 
• are willing to use reliable contraception during the trial and for a period after if there is any chance you or your partner could become pregnant
• are fit and active but might not be able to do heavy physical work (performance status 0 to 1)
• are at least 18 years old 

Who can’t take part

Cancer related 
You can’t take part if any of the following apply. You:

• have cancer that has spread to the brain, spinal cord or thin layer of tissues that cover the brain. Your doctor will know this. 
• are currently having another cancer treatment. This could include immunotherapy , chemotherapy or a targeted cancer drug 
• have had a type of drug called a monoclonal antibody within 4 weeks of starting trial treatment. You can’t take part if you have side effects from having a monoclonal antibody in the past that are moderate to severe. 
• have had an immunotherapy or a similar treatment in the past. Your doctor will know this. 
• have had any other cancer treatment to the whole body within 4 weeks of starting trial treatment 
• have had radiotherapy within 2 weeks of starting trial treatment or you have side effects from radiotherapy and need to have steroids
• have another cancer that is getting worse or you needed treatment for another cancer in the last 2 years 
• are taking an experimental drug or using a device as part of another clinical trial. This is if it is within 4 weeks of joining this trial. 

Medical conditions
You cannot join this trial if any of these apply. You:

• have a significant heart problem that could affect you taking part. The trial team will check if you have a heart condition before you join the trial. 
• have HIV that isn’t well controlled with medication. You can’t take part if you have had Kaposi’s sarcoma, Multicentric Castleman’s disease or both.
• have hepatitis B or hepatitis C that isn’t under control or you have hepatitis B and hepatitis C at the same time
• have fluid around your heart or lungs
• have a problem with how your immune system works or you had treatment that damps down the immune system. This includes steroids within 2 weeks of starting trial treatment unless it was a low dose. 
• have an autoimmune condition that needed treatment in the last 2 years apart from certain ones. Your doctor will know about this. 
• have scarring on the lungs or active inflammation of the lungs (pneumonitis ) or you have had this in the past
• have an active infection that needs treatment to the whole body 
• have had an organ transplant in the past or a stem cell transplant with somebody else’s cells in the last 5 years. You might be able to take part if you had the stem cell transplant more than 5 years ago as long as you don’t have graft versus host disease . Your doctor will know about this. 
• haven’t fully recovered from major surgery or you have complications following surgery 
• have another medical condition or mental health condition that could affect you taking part

Other 
You cannot join this trial if any of these apply. You:

• have had a live vaccine within 30 days of the start of treatment. Please note that the COVID-19 vaccine is allowed as it isn’t a live vaccine.
• are allergic to pembrolizumab, MK-5180 (hyaluronidase) or anything they contain 
• are pregnant or breastfeeding