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A trial looking at brenetafusp and nivolumab for advanced melanoma (PRISM-MEL-301)

Overview

Cancer types:

Melanoma, Secondary cancers, Skin cancer

Status:

Open

Phase:

Phase 3

Details

This trial is looking at a new combination of treatment with brenetafusp and nivolumab. It is comparing this to with nivolumab on its own or with relatlimab.

It is for people with melanoma of the skin:

  • that can’t be removed with surgery or

  • that has spread to another part of the body

Please note, you can’t take part if you have melanoma of the eye (uveal melanoma).

Recruitment start: 10 July 2024

Recruitment end: 27 December 2027

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor James Larkin

Supported by

Immunocore

Last reviewed: 08 Oct 2025

CRUK internal database number: 20043

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