Anal cancer
Results
Phase 2
This trial looked at giving less treatment to people with very early stage anal cancer (stage 1) that had been removed with surgery.
The trial was supported by Cancer Research UK. People could join between 2017 and 2023. The team prepared a summary in 2025 about the results from the first 6 months.
The ACT3 trial is part of a group of trials called PLATO. This stands for PersonaLising Anal cancer radioTherapy dOse.
The other trials include:
PLATO ACT 4, which looked at reducing the dose of chemoradiotherapy for people with anal cancer that had not spread.
PLATO ACT 5, which looked at higher doses of chemoradiotherapy for people with anal cancer that had spread.
Recruitment start: 13 January 2017
Recruitment end: 31 August 2023
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor David Sebag-Montefiore
Cancer Research UK
Stand Up To Cancer
University of Leeds
This is Cancer Research UK trial number CRUK/15/007.
Last reviewed: 11 Mar 2026
CRUK internal database number: 13381
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