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A trial looking at amivantamab for a brain tumour called glioblastoma (5G-EMERALD)

Overview

Cancer types:

Brain (and spinal cord) tumours

Status:

Open

Phase:

Phase 1

Details

This trial is looking at amivantamab for glioblastoma.

It is for people whose brain tumours have come back or the last treatment didn’t work.

You pronounce amivantamab as amee-van-tah-mab.

The 5G-EMERALD trial is part of a large research programme looking at new treatments for brain tumours. The research programme is called 5G: A Next-Generation aGile Genomically Guided Glioma platform trial. It is called the 5G platform trial for short.

Cancer Research UK supports this trial.

Recruitment start: 24 October 2024

Recruitment end: 28 July 2026

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Juanita Lopez

Supported by

Institute of Cancer Research (ICR)

Cancer Research UK

Minderoo Foundation

The Royal Marsden NHS Foundation Trust

Cambridge University Hospitals NHS Foundation Trust

University of Cambridge

Other information

This is Cancer Research UK trial number CRUK/23/004.

Last reviewed: 02 Feb 2026

CRUK internal database number: 20140

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