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A trial of ibrutinib with or without other treatments for chronic lymphocytic leukaemia (FLAIR)

Overview

Cancer types:

Blood cancers, Chronic leukaemia, Chronic lymphocytic leukaemia (CLL), Leukaemia

Status:

Results

Phase:

Phase 3

Details

This trial compared the at the time to ibrutinib alone or with rituximab or venetoclax, for chronic lymphocytic leukaemia. It was for people who hadn’t had treatment yet.

The trial was supported by Cancer Research UK. It was open for people to join between 2014 and 2024. The team published results in several medical journals between 2021 and 2024. They plan to publish more in the future.

Recruitment start: 21 August 2014

Recruitment end: 19 January 2024

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Talha Munir

Supported by

Cancer Research UK

Abbvie

Janssen Pharmaceuticals

University of Leeds

Other information

This is Cancer Research UK trial number CRUK/12/037.

Last reviewed: 17 Oct 2025

CRUK internal database number: 10515

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