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A trial of docetaxel with or without selumetinib for advanced melanoma (DOC-MEK)

Overview

Cancer types:

Melanoma, Skin cancer

Status:

Results

Phase:

Phase 2

Details

This trial looked at docetaxel with or without selumetinib (AZD6244) for people whose melanoma cells didn’t have a change () in a gene called BRAF. This trial was for people whose melanoma had spread to the surrounding or to another part of the body. This is called advanced melanoma.

Doctors sometimes use chemotherapy drugs such as docetaxel (Taxotere) to treat advanced melanoma. But it doesn’t always work very well. Doctors hoped that using a new treatment called selumetinib with docetaxel may have worked better than docetaxel alone.

Selumetinib is a type of drug called a MEK inhibitor and it works by blocking growth signals. MEK is a protein that sends signals to cells telling them to divide and grow. Researchers hoped that selumetinib would reduce the amount of MEK and slow down or stop the growth of cancer.

The aims of this trial were to find out

  • If docetaxel and selumetinib was better than docetaxel alone for advanced melanoma with no BRAF gene change

  • More about the side effects

Recruitment start: 26 October 2010

Recruitment end: 21 May 2012

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Prof Mark Middleton

Supported by

AstraZeneca

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

NIHR Clinical Research Network: Cancer

NIHR Oxford Biomedical Research Centre

University of Oxford

Other information

This is Cancer Research UK trial number CRUKE/10/026.

Last reviewed: 11 September 2016

CRUK internal database number: 6195

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