A trial of ASA404 and docetaxel for non small cell lung cancer that has continued to grow during chemotherapy or has come back after treatment (ATTRACT 2)

This trial was looking at a drug called ASA404 in combination with the chemotherapy drug docetaxel for non small cell lung cancer (NSCLC) that was stage 3B or 4.

Doctors often use chemotherapy to treat NSCLC that is locally advanced or has spread to another part of the body. If NSCLC continues to grow, or comes back after treatment, you may have more chemotherapy. Docetaxel is a drug that doctors may use.

Cancer cells need a blood supply to help them grow and survive. Growing cancer cells can encourage the growth of new blood vessels. This is called angiogenesis.

In this trial, researchers were looking at a drug called ASA404 which targets the cancer’s blood supply and might have helped to stop the cancer growing. They compared ASA404 with a dummy drug (a placebo). The aims of the trial were to

• Find out if ASA404 worked better than the dummy drug, when you have it with docetaxel for NSCLC that had continued to grow during chemotherapy or had come back after treatment

• Learn more about the side effects and how they affected people’s quality of life