A study looking at a way to check if chemotherapy is working for non Hodgkin lymphoma and Hodgkin lymphoma (BiLD)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers
High grade lymphoma
Hodgkin lymphoma
Low grade lymphoma
Non-Hodgkin lymphoma





This study is looking for substances in the blood that may tell doctors that chemotherapy for non Hodgkin lymphoma and Hodgkin lymphoma is working.

More about this trial

Doctors use chemotherapy to treat non Hodgkin lymphoma and Hodgkin lymphoma. During treatment they use CT scans or PET-CT scans to see if the treatment is working.

In this study the researchers want to see if they can use substances in the blood (biomarkers Open a glossary item) and another type of scan called a MRI scan to predict how well the chemotherapy is working.

Who can enter

You may be able to join this study if you are

You cannot join this study if you are pregnant or breastfeeding.

Trial design

The researchers need 50 people to join this study. You will give blood samples

  • Before starting chemotherapy
  • 8 days after starting chemotherapy
  • Before each chemotherapy treatment
  • At the end of chemotherapy
  • Every 3 months for at least 2 years or until your lymphoma comes back

You will also have an

  • MRI scan before starting chemotherapy
  • MRI scan and a CT scan or PET-CT scan 8 days after starting chemotherapy
  • MRI scan 6 to 8 weeks after finishing chemotherapy

The researchers will ask for a sample of your lymphoma that was removed when you had surgery or a biopsy Open a glossary item.

The researchers will also ask you to rinse your mouth with salt water for 30 seconds and then spit it into a container. This is to get a sample of your normal DNA Open a glossary item.

Hospital visits

You see the doctor to have a physical examination before taking part in this study.

You need to make 2 extra visits to the hospital for the scans.

Side effects

There is a very low risk that you may have an allergic reaction to the injection used for the MRI scans.

Taking part in this study means you will be exposed to some extra radiation during the extra scans. The amount of radiation you will receive is about the same as the average amount of background radiation from 18 years living in England. The trial team will answer any questions you have about this.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Shireen Kassam

Supported by

Elimination of Leukaemia Fund
King's College London
Kings College Hospital NHS Foundation Trust
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

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"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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