A study looking at the genetics of breast cancer

Cancer type:

Breast cancer





This study is trying to find out more about the genes that might cause breast cancer. It is only open to people living in Sheffield and South Yorkshire.

The researchers will look at the family history Open a glossary item and genes of a large number of people with breast cancer and compare them with people who do not have breast cancer.

The aim of this study is to identify genes that may cause breast cancer.

Please note you won’t get any direct benefit from taking part in this study, nor will it affect any treatment you have. The findings may help people with breast cancer in the future.

Who can enter

You can enter this trial if you have been diagnosed with breast cancer in the last year and

  • Live in Sheffield or South Yorkshire
  • Are attending the surgical outpatient’s clinic at the Royal Hallamshire Hospital Sheffield OR having radiotherapy or chemotherapy at Weston Park Hospital Sheffield

You cannot enter this trial if you are known to have inherited a gene that is known to increase cancer risk.

This trial will also recruit women between the age of 50 and 65 who do not have breast cancer and are attending the Sheffield Mammography Open a glossary item Service.

Trial design

This study will recruit 1,350 women with breast cancer and 1,350 who do not have breast cancer.

A member of the research team will interview you. They will ask you questions about yourself and the history of cancer in your family, for example who has or had cancer and at what age it was diagnosed. They will also take a blood sample.

If you have breast cancer and have had a tissue sample (biopsy) taken, or are due to have a biopsy, the researchers will ask your permission to request a small piece of tissue from it.

If you agree to take part in this study your samples will be safely stored in the Breast Cancer Now Tissue Bank and may be used in future research. If you don’t want your samples to be stored you don’t have to agree to this. You can still take part in the study.

Hospital visits

There are no extra hospital visits if you take part in this study.

Side effects

You may feel some slight discomfort from where the blood sample is taken.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Angela Cox

Supported by

Breast Cancer Now
Experimental Cancer Medicine Centre (ECMC)
Sheffield Teaching Hospitals NHS Foundation Trust
Yorkshire Cancer Research

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Deborah wanted to help other breast cancer patients in the future

A picture of Deborah

“Deborah agreed to take part in a trial as she was keen to help other cancer patients in the future. "If taking part in a trial means others might be helped then I’m very happy with that."

Last reviewed:

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