A study looking at the genetic causes of chronic lymphocytic leukaemia

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers
Chronic leukaemia
Chronic lymphocytic leukaemia (CLL)





This study is trying to find out more about the causes of chronic lymphocytic leukaemia and to identify genes that may be important in the development of this cancer.

There are a few known risk factors for chronic lymphocytic leukaemia. We know that CLL can run in families, but so far we haven’t found any specific gene changes that are linked to CLL.

In this study, the researchers will look at the genes of a large number of people who have chronic lymphocytic leukaemia (CLL). They will also ask them about their family history.

The aim of the study is to identify genes that could increase the risk of CLL.

Who can enter

You can enter this trial if you have chronic lymphocytic leukaemia (CLL).

Trial design

This study will recruit 5,000 people in the UK with chronic lymphocytic leukaemia (CLL). When you go to see your doctors, they may ask you if you are interested in taking part in the study.

If you agree to take part, you will be asked to fill in a questionnaire. It will ask about your relatives and whether they have had any type of cancer.

You will be asked to give a small sample of blood. You may give this at your GP surgery or hospital.

The DNA from your sample will be safely stored and only used in this study. The researchers will look at the DNA to try and find genes that may increase the risk of developing CLL. The DNA sample is taken for the purpose of this study only.

The researchers may want to contact other members of your family. But they will ask you before they do.

Hospital visits

Taking part in this study does not involve any extra hospital visits.

Side effects

The only side effect may be some slight bruising and discomfort from where the researchers took the blood sample.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Richard Houlston

Supported by

Institute of Cancer Research (ICR)
National Institute for Health Research Cancer Research Network (NCRN)

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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