“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A study looking at a diffusion weighted MRI scan to check for bowel cancer spread (SERENADE)
This study is to see if a scan called a diffusion weighted MRI may help to show up areas of cancer spread more clearly than a CT scan. The study is for people newly diagnosed with bowel cancer who are having a scan to check for cancer spread to the liver.
More about this trial
Researchers think that a type of MRI scan called diffusion weighted MRI (DW MRI) may be better than a standard CT scan at finding areas of bowel cancer that have spread to the liver. In this study, they want to see how well this scan works for people newly diagnosed with bowel cancer who have a high risk of their cancer spreading or coming back after treatment.
The study will compare the DW MRI scan with a standard CT scan to see which is better at finding possible cancer spread to the liver.
Who can enter
You may be able to join this study if all of the following apply. You
- Have a type of bowel cancer called
- Have already had a CT scan which didn’t show any signs of cancer spread to your liver
- Have a high risk of your bowel cancer spreading or coming back after treatment (your doctor can tell you more about this)
- Are at least 18 years old
You cannot join this study if any of these apply.
- Your cancer has spread to another part of your body
- You have already had chemotherapy for bowel cancer
- You cannot have an MRI scan for any reason, such as feeling very uncomfortable in small spaces, or having metal or a
pacemakerin your body
- You have any other cancer apart from non melanoma skin cancer
- You are pregnant or breastfeeding
The study team need 255 people to take part.
Everyone will have a diffusion weighted MRI scan (DW MRI) of their liver. DW MRI looks at the movement of water molecules, which show up differently in cancerous tissue and healthy tissue.
The timing of this scan depends on the type of bowel cancer you have.
If you have cancer of the back passage (rectal cancer) and you are having chemotherapy and radiotherapy, you have this first, followed by a routine MRI scan when you finish treatment. You have the diffusion weighted MRI scan of the liver at the same time as the MRI scan of your rectum.
If you have colon cancer, you have the diffusion weighted MRI scan of the liver within 4 weeks of joining the study.
If you have colon cancer you will have 1 extra hospital visit for the DW MRI scan. The scan takes about 10 minutes. If you have rectal cancer you will not need to have any extra visits as the liver scan will be done as part of your routine MRI scan.
You should not have any side effects from taking part in this study.
How to join a clinical trial
Professor Gina Brown
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
Pelican Cancer Foundation
Royal Marsden Biomedical Research Centre
The Royal Marsden NHS Foundation Trust