A study looking at a blood test for early stage non small cell lung cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer
Non small cell lung cancer

Status:

Closed

Phase:

Other

This study is looking at developing a blood test for early stage non small cell lung cancer.  

A lung cancer tumour can shed tiny pieces of DNA Open a glossary item into the blood. This is called circulating tumour DNA (ctDNA). In this study doctors want to see if they can find ctDNA in early stage non small cell lung cancer  (NSCLC).  The study is for people with a type of NSCLC called adenocarcinoma Open a glossary item, who are due to have surgery.

More about this trial

The doctors also want to

  • Learn about any changes to ctDNA after surgery for NSCLC
  • See whether ctDNA can be used to identify people who are at a high risk of the cancer coming back

You may not get any direct benefit from taking part in this study, and it is unlikely to affect any treatment you have. But it may help people in the future.

Who can enter

You may be able to join this study if you are going to have lung cancer surgery at St George’s Hospital in London and you

  • Have a type of non small cell lung cancer called adenocarcinoma
  •  Are due to have surgery to remove either part of your lung (lobectomy) or your whole lung (pneumonectomy)
  • Are at least 18 years old

You cannot join this study if any of these apply. You

  • Are not fit enough to have surgery to remove the cancer from your lung cancer
  • Have had anti cancer treatment that reaches your whole body (systemic treatment) for your lung cancer

Trial design

This study is for people due to have lung cancer surgery at St George’s Hospital in London. Doctors need up to 60 people to take part.

The doctors will ask for 3 extra blood samples from you

  • Before surgery
  • Before you go home following your surgery
  • At your 1st follow up appointment after surgery

These are extra blood tests.

The doctors will also ask you if they can keep a sample of your lung cancer after it is removed. They use this and the blood samples to look for the ctDNA.

Hospital visits

There are no extra hospital visits associated with taking part in this study.

Side effects

There are no side effects associated with taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Sanjay Popat

Supported by

Biomedical Research Centre (BRC)
NIHR Clinical Research Network: Cancer
The Institute of Cancer Research (ICR)
The Royal Marsden NHS Foundation Trust
Wellcome Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

12810

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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