Stage 1 anal cancer

Stage 1 anal cancer means that the cancer is less than 2cm in size. And it hasn't spread to any nearby tissue, lymph nodes Open a glossary item or other organs. 

Anal cancer can start in different cell types. This information is for squamous cell cancer Open a glossary item which is the most common type of anal cancer.

Diagram showing stage 1 anal cancer

TNM staging

Doctors also use another staging system for anal cancer. They call this the TNM staging system. It stands for tumour, node and metastasis: 

  • T describes the size of the tumour
  • N describes whether there are any cancer cells in the nearby lymph nodes
  • M describes whether the cancer has spread elsewhere in the body

The TNM system describes the cancer in detail. The number staging system puts these details together to give an overall stage. 

Number stage 1 is the same as T1, N0 and M0 in the TNM staging system.

Treatment for stage 1 anal cancer

Knowing the stage of the cancer helps your doctor to decide which treatment is best for you. Treatment can also depend on:

  • whether the cancer is in the anal margin Open a glossary item or anal canal
  • if the cancer involves your sphincter muscles
  • your general health

Cancer in the anal margin

You might have an operation called a local excision if the cancer is in the anal margin. And if the cancer doesn't involve the sphincter muscles. These are the muscles that control your bowel movements.

Diagram showing the anatomy of the anus

During the operation, your surgeon removes the cancer and a healthy area of tissue around it. This area is called the margin.

Some people may have a combination of chemotherapy and radiotherapy (chemoradiotherapy) after a local excision. This is normally if their doctor thinks there are still some cancer cells nearby.

You need to be generally fit and well to have an operation. If you are not able to have surgery, your doctor will talk to you about other treatment options. This may include chemoradiotherapy instead of an operation.

Cancer in the anal canal or affecting the sphincter muscles

You normally have chemoradiotherapy if the cancer involves either your: 

  • anal sphincter muscles
  • anal canal 

This is usually instead of a local excision.

When you have finished your treatment, your doctor will check that the cancer has completely gone.

If your doctor thinks there are still cancer cells

If your doctor thinks there is any cancer left after chemoradiotherapy, they take a sample of tissue (biopsy) from the area. If this contains cancer cells, they will talk to you about further treatment. This may include a large operation called an abdominoperineal resection (APR). Your surgeon and anaesthetist Open a glossary item will make sure you are well enough to have this surgery.

Other stages of anal cancer

  • AJCC Cancer Staging Manual (8th edition)
    American Joint Committee on Cancer
    Springer, 2017

  • Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    S Rao and others
    Annals of Oncology, 2021. Volume 32, Issue 9, Pages 1087-1100

  • Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Anal Cancer
    I Geh and others
    Colorectal Disease, 2017. Volume 19, Issue S1, Pages 82-97

  • Anal Cancer
    BMJ Best Practice
    Accessed May 2025

  • Abdominoperineal Resection
    G Menon and others
    National Library of Medicine (StatPearls)
    Accessed May 2025

  • The information on this page is based on literature searches and specialist checking. We used many references and there are too many to list here. Please contact patientinformation@cancer.org.uk if you would like to see the full list of references we used for this information.

Last reviewed: 
08 May 2025
Next review due: 
08 May 2028

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