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Thyroid cancer risk

Older age is the main risk factor for cancer. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors.

This page covers other factors with the best evidence of an association with cancer risk; this list is not exhaustive.

See our other pages for general information about cancer, or ways to reduce your risk.

More thyroid cancer statistics

Incidence

Mortality

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Acknowledgements

We are grateful to the many organisations across the UK which collect, analyse, and share the data which we use, and to the patients and public who consent for their data to be used.

Find out more about the sources which are essential for our statistics

References

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    Lifetime risk estimates calculated by the Cancer Intelligence Team at Cancer Research UK 2023.

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    Sasieni PD, Shelton J, Ormiston-Smith N, et al. What is the lifetime risk of developing cancer?: The effect of adjusting for multiple primaries. Br J Cancer, 2011.105(3): p.460-5

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    Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body Fatness and Cancer--Viewpoint of the IARC Working Group. N Engl J Med. 2016 Aug 25;375(8):794-8.

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    Kyrgiou M, Kalliala I, Markozannes G, et al. Adiposity and cancer at major anatomical sites: umbrella review of the literature. BMJ 2017;:j477.

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    International Agency for Research on Cancer. List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 122*. Accessed October 2018.

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    Calculated by the Statistical Information Team at Cancer Research UK, 2018. Based on Brown KF, Rumgay H, Dunlop C, et al. The fraction of cancer attributable to known risk factors in England, Wales, Scotland, Northern Ireland, and the UK overall in 2015. British Journal of Cancer 2018.

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    Veiga LH, Lubin JH, Anderson H, et al. A pooled analysis of thyroid cancer incidence following radiotherapy for childhood cancer. Radiat Res 2012;178(4):365-76.

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    Neta G, Rajaraman P, Berrington de Gonzalez A, et al. A prospective study of medical diagnostic radiography and risk of thyroid cancer. Am J Epidemiol 2013;177(8):800-9.

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    Furukawa K, Preston D, Funamoto S, et al. Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure. Int J Cancer 2013;132(5):1222-6.

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    Spallek L, Krille L, Reiners C, et al. Adverse effects of iodine thyroid blocking: a systematic review. Radiat Prot Dosimetry 2012;150(3):267-77.

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    Frank C, Fallah M, Ji J, et al. The population impact of familial cancer, a major cause of cancer. Int J Cancer. 2014; 134(8):1899-906

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    Nosé V. Familial thyroid cancer: a review. Mod Pathol 2011;24 Suppl 2:S19-33.

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    Jarrar AM, Milas M, Mitchell J, et al. Screening for thyroid cancer in patients with familial adenomatous polyposis. Ann Surg 2011;253(3):515-21.

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    Herraiz M, Barbesino G, Faquin W, et al. Prevalence of thyroid cancer in familial adenomatous polyposis syndrome and the role of screening ultrasound examinations. Clin Gastroenterol Hepatol 2007;5(3):367-73.

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    Smith-Bindman R, Lebda P, Feldstein VA, et al. Risk of thyroid cancer based on thyroid ultrasound imaging characteristics: results of a population-based study. JAMA Intern Med 2013;173(19):1788-96.

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    Mehanna HM, Jain A, Morton RP, et al. Investigating the thyroid nodule. BMJ 2009;338:b733.

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    Brito JP, Gionfriddo MR, Al Nofal A, et al. The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis. J Clin Endocrinol Metab 2014;99(4):1253-63.

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