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Getting diagnosed with cancer of unknown primary (CUP)

Seeing your GP

Visit your GP if you notice something that isn't normal for you or if you have any of the possible signs and symptoms of cancer. They examine you and might refer you for tests or to see a specialist.

It's unlikely that your GP will suspect that you have cancer of unknown primary (CUP) at this stage. 

Even if you're worried about what the symptom might be, don't delay seeing them. Your worry is unlikely to go away if you don't make an appointment. The symptoms might not be due to cancer. But if it is, the earlier it's picked up the higher the chance of successful treatment. You won't be wasting your doctor's time.

Try not to be embarrassed. What you tell your GP is confidential. Doctors are used to discussing intimate problems and will try to put you at ease.

General cancer symptoms

Getting the most out of your GP appointment

You may have your appointment in person, over the telephone or as a video call. However, when you speak to your GP it can be difficult to remember everything you want to say. These tips will help you get the most out of your appointment.

Tips

  • Write down your symptoms including when they started, when they happen and how often you have them.

  • Write down anything that makes them worse or better.

  • If you would prefer to only see a male doctor or female doctor, ask when you book the appointment - the receptionist will tell you if it is possible.

  • Tell your GP if you are worried about cancer.

  • Tell them if you have any family history of cancer.

  • Have a friend or relative with you for support - they could also ask questions and take notes to help you remember what the GP says.

  • Ask the GP to explain anything you don’t understand.

  • Ask the GP to write things down for you if you think it might help - if you have a telephone or video appointment ask for the information to be left at reception for you to pick up.

Tips for telephone appointments

You might have a telephone appointment with your GP instead of a face to face. You can watch a video with top tips for phone and digital appointments with your doctor. The video lasts 1 minute and 43 seconds.

What happens during your GP appointment

Your doctor will ask about your symptoms:

  • what they are

  • when you get them

  • whether anything makes them better or worse

They will also ask you about your general health. GP appointments usually only last for a few minutes. So your doctor might ask you to arrange another appointment to talk to you in more detail.

Tests your GP might do

Your doctor might take your blood pressure and pulse (heart rate). Depending on your symptoms, they may also do a general physical examination. They feel for any areas that might be swollen or might not feel normal. If you have any pain they will feel those areas. It might feel tender, or it might be possible to feel a lump.

They may also listen to your chest to find out if it sounds normal. For example, they can listen for signs of fluid collecting.

After your examination, your doctor might arrange for you to have some blood tests. These are usually done at the GP practice. They might also refer you to the hospital for tests or to see a specialist. 

Referral to a specialist

Your GP might refer you to a hospital to see a specialist if you have symptoms that could be due to cancer. 

Read about specialist referral

Questions you might want to ask your GP

  • Do I need to see a specialist? Is it urgent?

  • When will I see them?

  • Where will I see them?

  • Will I find out about my appointments by post or telephone?

  • Do I need tests? What will they involve?

  • How long should I expect to wait?

  • Where can I find out more about tests?

  • Do I have to do anything in preparation for this test?

  • When will I get the results and who will tell me?

Your GP might not be able to answer all of your questions. They will tell you what they can at this point. Not knowing is difficult to cope with and can make you anxious.

Speaking to a friend or relative about how you feel might help.

If your GP doesn't think you need any tests or a referral

  • Can you explain why I don’t need to have tests or see a specialist?

  • Is there anything I can do to help myself?

  • Do I need to see you again?

  • Who do I contact if my symptoms continue or get worse, especially during the night or at weekends?

What happens next?

Make sure you know what happens next. Make another appointment if your symptoms don’t clear up, or if they change or get worse.

How to find a GP

If you don’t have a GP, you can find a doctor’s surgery in your local area by going to:

Making an appointment

To make an appointment you:

  • can telephone your GP surgery

  • can book an appointment online through your GP surgery website (if they have one)

  • may be able to use the NHS App

  • may be able to go into the GP surgery and make an appointment in person

Find out more about the NHS App and how to register

If it's difficult to get through to the GP surgery by phone try calling at a different time of the day. Or try calling on a different day. It could be particularly busy in the mornings or on a Monday. Although it can be frustrating you should keep trying. Some GP surgeries offer to call you back if you are in a telephone queue.  

You might be able to go to your GP surgery to book an appointment. But not all surgeries offer this service. It may help to see if your GP surgery has a website - this will explain the best way to get an appointment. 

You don’t have to tell the receptionist why you want to see the doctor, although sometimes it might help to explain your situation.

The reception team are trained in offering you an appointment with the most suitable professional at the right time. Depending on your symptoms, you might see another healthcare professional such as a nurse first.

You may be asked to attend in person, especially if your GP needs to examine you. Or the receptionist may offer you a telephone or video appointment first. If your GP needs to see you after this they will ask you to make another appointment. The receptionist will give you a date and time for this. 

Accept a booked appointment even if you think it’s a long time to wait. You could ask about cancellations if you're able to get to the surgery at short notice. Check that the surgery has the right details for you, including your telephone number and email.  

Contact the GP surgery again if your symptoms change or get worse.

Find out what might happen if your GP refers you to a specialist or for tests:

Seeing a specialist

Last reviewed: 15 May 2024

Next review due: 15 May 2027

What is cancer of unknown primary (CUP)?

Cancer of unknown primary (CUP) means that cancer spread (secondary cancer) has been found in your body, but doctors don't know where the cancer started (the primary tumour).

Referral to a specialist

Your GP can arrange for you to see a specialist doctor. Find out which specialist you might see and what to expect.

Tests for CUP

The tests you have to diagnose CUP depend on your symptoms and where in your body the cancer is.

Treatment for CUP

Treatment for CUP depends on a number of things, including where the cancer is and your general health. You might have a targeted cancer drug or chemotherapy. Sometimes you may have surgery or radiotherapy to help control your symptoms.

Living with CUP

Advice and support is available to help you cope with cancer of unknown primary (CUP) and its treatment.

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