Cancer of unknown primary (CUP)
Most people are diagnosed with cancer of unknown primary (CUP) after they become unwell and go to accident and emergency (A&E). Others start by seeing their GP if they have symptoms that could be due to cancer.
If your tests show that you have cancer that has spread (a secondary cancer), you may have further tests to look for where the cancer started (the primary tumour) and to see if it has spread anywhere else in the body. If doctors can't find the primary cancer, it is CUP.
Sometimes doctors find the primary cancer at a later date. When this happens, the cancer is no longer a CUP and your treatment will follow the guidelines for the specific cancer type.
You should see your GP if you notice a change that isn't normal for you. They will examine you and might refer you for tests or to a specialist.
Your GP can arrange for you to see a specialist doctor. Find out which specialist you might see and what to expect.
The tests you have to diagnose CUP depend on your symptoms and where in your body the cancer is.
Last reviewed: 15 May 2024
Next review due: 15 May 2027
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