Stage 4 anal cancer

Stage 4 anal cancer means the cancer has spread to other parts of the body, such as the liver. The cancer can be any size and may or may not have spread to the nearby lymph nodes.

Unfortunately, cancer that has spread elsewhere in the body is advanced cancer.

Diagram showing anal cancer that has spread to the liver

Anal cancer can start in different cell types. This information is for squamous cell cancer Open a glossary item which is the most common type of anal cancer.

TNM staging

Doctors also use another staging system for anal cancer. They call this the TNM staging system. It stands for tumour, node and metastasis: 

  • T describes the size of the tumour
  • N describes whether there are any cancer cells in the nearby lymph nodes
  • M describes whether the cancer has spread elsewhere in the body

The TNM system describes the cancer in detail. The number staging system puts these details together to give an overall stage. 

Number stage 4 is the same as any T, any N, M1 in the TNM staging system.

Treatment for stage 4 anal cancer

Knowing the stage of the cancer helps your doctor to decide which treatment is best for you. Treatment can also depend on:

  • where the cancer is in your anus
  • your general health

The aim of treatment for stage 4 anal cancer is to slow down the growth of the cancer.

Chemotherapy

Chemotherapy is the main treatment for advanced anal cancer. It uses anti cancer drugs to destroy cancer cells. These drugs are also called cytotoxic drugs. They circulate throughout the body in the bloodstream.

Best supportive care

If you’re not fit enough for chemotherapy, your doctor might suggest best supportive care. This is also called palliative care. It aims to relieve the symptoms of the cancer and improve your quality of life Open a glossary item. Treatments may include radiotherapy Open a glossary item and surgery.

Other stages of anal cancer

  • AJCC Cancer Staging Manual (8th edition)
    American Joint Committee on Cancer
    Springer, 2017

  • Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    S Rao and others
    Annals of Oncology, 2021. Volume 32, Issue 9, Pages 1087-1100

  • Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Anal Cancer
    I Geh and others
    Colorectal Disease, 2017. Volume 19, Issue S1, Pages 82-97

  • Anal Cancer
    BMJ Best Practice
    Accessed May 2025

  • Clinical Oncology: Radiotherapy Dose Fractionation (4th edition)
    Royal College of Radiologists, 2024

  • The information on this page is based on literature searches and specialist checking. We used many references and there are too many to list here. Please contact patientinformation@cancer.org.uk if you would like to see the full list of references we used for this information.

Last reviewed: 
20 May 2025
Next review due: 
20 May 2028

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