Non-Hodgkin lymphoma (NHL) (all subtypes combined) is the sixth most common cancer in the UK (2012), accounting for 4% of all new cases. In males, it is the fifth most common cancer (4% of the male total), whilst it is the seventh in females (4%).[1-4]
In 2012, 12,900 new cases of NHL were registered in the UK: 7,007 (54%) in males and 5,893 (46%) in females, giving a male:female ratio of around 12:10.[1-4] The
Differences in registration methods, diagnosis and classification are likely to have a bearing on comparisons between the countries and regions within the UK. For males, the estimated European
Non-Hodgkin Lymphoma (C82-C85), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2012
|AS Rate - 95% LCL||26.2||20.6||22.5||26.9||25.9|
|AS Rate - 95% UCL||27.5||25.7||26.6||35.3||27.2|
|AS Rate - 95% LCL||18.5||14.6||17.6||18.6||18.5|
|AS Rate - 95% UCL||19.6||18.5||20.9||25.0||19.5|
|AS Rate - 95% LCL||22.2||18.0||20.2||23.4||22.1|
|AS Rate - 95% UCL||23.1||21.2||22.8||28.6||22.8|
95% LCL and 95% UCL are the 95% lower and upper
Though variation in NHL incidence across the UK has been reported[6-8] an analysis comparing reported incidence with the expected incidence based on Haematological Malignancy Research Network (HMRN) rates found that this variation is most likely artefactual.
Using HMRN data for 2004-2011, it is estimated that almost half of all NHL cases diagnosed in the UK are diffuse large B-cell lymphoma (Diffuse large B-cell lymphoma (DLBCL), 48%). Marginal zone lymphomas (MZL) and follicular lymphoma (FL) account for a further one-fifth of cases each (20% and 19%, respectively), with T-cell lymphomas (6%), mantle cell lymphoma (MCL, 5%) and Burkitt lymphoma (2%) making up the remainder. Crude incidence rates range from 0.5 (Burkitt lymphoma) to 9 (DLBCL) cases for every 100,000 men in the UK, and from 0.2 (Burkitt lymphoma) to 8 (DLBCL) cases for every 100,000 women in the UK.
HMRN’s European AS incidence rates are significantly higher in males than females for five of the six main NHL subtypes; the exception is FL, where rates do not differ significantly between the sexes.
Non-Hodgkin Lymphoma Subtypes, Expected Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK (Estimates Based on HMRN data), 2004-2011
|Cases||AS Rate (95% LCL-95% UCL)||Cases||AS Rate (95% LCL-95% UCL)||Cases||AS Rate (95% LCL-95% UCL)|
|B-cell||Diffuse large B-Cell Lymphoma||2,532||7.8 (7.6-8)||2,199||5.6 (5.4-5.7)||4,835||6.6 (6.5-6.7)|
|Marginal Zone Lymphomas||1,073||3.2 (2.5-2.6)||847||2.0 (1.9-2.1)||1,962||2.5 (2.5-2.6)|
|Follicular Lymphoma||857||2.7 (2.6-2.8)||998||2.8 (2.7-2.9)||1,884||2.8 (2.7-2.8)|
|Mantle Cell Lymphoma||331||1 (0.9-1.1)||181||0.4 (0.3-0.4)||513||0.6 (0.6-0.7)|
|Burkitt Lymphoma||152||0.5 (0.4-0.6)||52||0.2 (0.1-0.2)||204||0.3 (0.3-0.4)|
|T-cell Lymphomas||350||1.1 (1-1.2)||254||0.7 (0.6-0.7)||604||0.9 (0.8-0.9)|
|Lymphoproliferative Disorders Not Otherwise Specified||608||1.8 (1.7-1.9)||509||1.0 (0.9-1.1)||1,116||1.3 (1.3-1.4)|
95% LCL and 95% UCL are the 95% lower and upper
ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.
- Data were provided by the Office for National Statistics on request, July 2014. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
- Data were provided by ISD Scotland on request, April 2014. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
- Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, April 2014. Similar data can be found here:http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
- Data were provided by the Northern Ireland Cancer Registry on request, June 2014. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
- Haematological Malignancy Research Network. Haematological malignancies & cancer registration in England (2004-2008). Quality appraisal comparing data from the National Cancer Data Repository (NCDR) with the population-based Haematological Malignancy Research Network (HMRN). Final Report. London: Leukaemia & Lymphoma Research; 2012.
- Quinn M, Wood H, Cooper N, et al, eds. Cancer Atlas of the United Kingdom and Ireland 1991-2000. Studies on Medical and Population Subjects No. 68. London: ONS; 2005.
- National Cancer Intelligence Network (NCIN). Cancer Incidence and Mortality by Cancer Network, UK, 2005. London: NCIN; 2008.
- National Cancer Intelligence Network (NCIN). Cancer e-Atlas. Accessed at: http://www.qub.ac.uk/research-centres/nicr/
- Data were provided by Haematological Malignancy Research Network (HMRN) on request.