Acute lymphoblastic leukaemia (ALL) incidence statistics

Cases

New cases of acute lymphoblastic leukaemia, 2013, UK

 

Proportion of all cases

Percentage acute lymphoblastic leukaemia is of total cancer cases, 2013, UK

 

Age

Age that more than half of acute lymphoblastic leukaemia cases are diagnosed, 2011-2013, UK

 

Trend since late-1970s

Acute lymphoblastic leukaemia incidence rates have changed differently for each sex since the late 1970s, GB

 

Acute lymphoblastic leukaemia (ALL) accounts for 0.2% of all new cancer cases in the UK, and 9% of all leukaemia subtypes combined (2013).[1-4]

In 2013, there were 818 new cases of ALL in the UK: 437 (53%) in males and 381 (47%) in females, giving a male:female ratio of around 11:10.[1-4] The crude incidence rate Open a glossary item shows that there is around 1 new ALL case for every 100,000 males in the UK and 1 for every 100,000 females.

The European age-standardised incidence rates Open a glossary item (AS rates) do not differ significantly between the constituent countries of the UK for either sex.[1-4]

Acute Lymphoblastic Leukaemia (C91.0), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2013

England Wales Scotland Northern Ireland UK
Male Cases 371 23 31 12 437
Crude Rate 1.4 1.5 1.2 1.3 1.4
AS Rate 1.3 1.4 1.1 1.0 1.3
AS Rate - 95% LCL 1.2 0.8 0.7 0.4 1.2
AS Rate - 95% UCL 1.5 2.0 1.5 1.6 1.4
Female Cases 322 20 31 8 381
Crude Rate 1.2 1.3 1.1 0.9 1.2
AS Rate 1.1 1.2 1.1 0.8 1.1
AS Rate - 95% LCL 1.0 0.7 0.7 0.3 1.0
AS Rate - 95% UCL 1.2 1.8 1.5 1.4 1.2
Persons Cases 693 43 62 20 818
Crude Rate 1.3 1.4 1.2 1.1 1.3
AS Rate 1.2 1.3 1.1 0.9 1.2
AS Rate - 95% LCL 1.1 0.9 0.9 0.5 1.1
AS Rate - 95% UCL 1.3 1.7 1.4 1.4 1.3

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
Last reviewed:

Acute lymphoblastic leukaemia (ALL) incidence is strongly related to age, with the highest incidence rates being in children, teenagers and young adults – the converse pattern to most cancers. In the UK in 2011-2013, on average each year more than half (54%) of cases were diagnosed in children aged 0-14.[1-4]

Age-specific incidence rates are highest in infants aged 0-4 and drop sharply through childhood, adolescence and young adulthood, reaching their lowest point at age 30-34 in males and 35-39 in females, and increasing slightly thereafter. Incidence rates are similar between males and females in all age groups except age 15-19, when age-specific rates are significantly higher for males than for females. At age 15-19 the male:female ratio of age-specific incidence rates (to account for the different proportions of males to females in each age group) is around 19:10.[1-4]

Acute Lymphoblastic Leukaemia (C91.0), Average Number of New Cases per Year and Age-Specific Incidence Rates, UK, 2011-2013

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
Last reviewed:

Acute lymphoblastic leukaemia (ALL) incidence rates have increased by 13% in Great Britain since the late 1970s.[1-3] However this includes an overall increase of 19% for females, and stable rates for males, and for both sexes there have been increases and decreases during this time.

For males, European age-standardised (AS) incidence Open a glossary item rates increased by 19% between 1979-1981 and 2004-2006, and have since remained stable. The trend is similar for females, with rates increasing 24% between 1979-1981 and 2002-2004 and have since remained stable.

Acute Lymphoblastic Leukaemia (C91.0), European Age-Standardised Incidence Rates, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Over the last decade in the UK (between 2002-2004 and 2011-2013), ALL AS incidence rates have remained stable, for males and females separately and for both sexes combined.[1-4]

Acute Lymphoblastic Leukaemia (C91.0), European Age-Standardised Incidence Rates, UK, 1993-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

ALL incidence trends probably reflect improvements in diagnostic techniques and data registration.[5,6]

ALL incidence rates have remained stable overall for most of the broad age groups in Great Britain since the late 1970s.[1-3] The largest change has been in people aged 25-49, with European AS incidence rates rising by 36% between 1979-1981 and 2011-2013. The smallest change has been in people aged 0-24, with rates rising by 18% between 1979-1981 and 2011-2013. Rates in the other age groups fluctuated during this time, but have remained stable overall.

Acute Lymphoblastic Leukaemia (C91.0), European Age-Standardised Incidence Rates, by Age, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
  5. Northern and Yorkshire Cancer Registry and Information Service. Haematological malignancies in England. Cancers Diagnosed 2001-2008. London: NCIN; 2013
  6. National Cancer Data Repository (NCDR). Blood Cancers Data Quality Report 2010. London:NCIN.
Last reviewed:

The lifetime risk of developing acute lymphoblastic leukaemia (ALL) is around 1 in 1,015 for men and around 1 in 1,340 for women, in 2012 in the UK.[1]

The lifetime risk for ALL has been calculated on the assumption that the possibility of having more than one diagnosis of ALL over the course of a lifetime is very low (‘Current Probability’ method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Esteve J, Benhamou E and Raymond L. Descriptive epidemiology. IARC Scientific Publications No.128, Lyon, International Agency for Research on Cancer, pp 67-68 1994.
Last reviewed:

There is evidence for a small association between acute lymphoblastic leukaemia (ALL) incidence and deprivation for males in England, making this one of the few cancers where incidence rates are lower for more deprived males. There is no evidence for an association between the incidence of ALL and deprivation for females.[1]

England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are 14% lower for males living in the most deprived areas compared with the least deprived, but for females the rates are similar for those living in the least and most deprived areas.[1]

Acute Lymphoblastic Leukaemia (C910), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

For males diagnosed with acute lymphatic leukaemia the deprivation gradient has gone from having higher incidence in the more deprived in 1996-2000 to having higher incidence rates in the less deprived in 2006-2010. The estimated deprivation gradient  in acute lymphatic leukemia incidence for females living in the most and least deprived areas in England has not changed in the period 1996-2020.

Last reviewed:

Cancer Statistics Explained

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