Recently funded awards

This page features a selection of awards we have supported at recent committee meetings.

Select a funding committee below to see what they have funded recently:

Research Bursaries

Dr Sameena Khan, University of Leicester

Investigating a curcumin-binding protein as a potential druggable target in colorectal cancer stem-like cells

Dr Louise Price, University of Birmingham

PRH/pPRH ratio as a marker of response to cisplatin sensitivity

Dr Kiruthikah Thillai, King’s College London

Does the activity of the PAK-PI3K signalling nexus promote pancreatic cancer tissue invasion?

Clinician Scientist Fellowships

Dr Imran Ahmad, University of Glasgow

Identification and Validation of New Therapeutic Targets in Enzalutamide-Resistant Prostate Cancer

Dr Geoff Higgins, University of Oxford

Elucidation of novel molecular mechanisms of radiation resistance and their application to clinical radiotherapy trials

Dr Michelle Lockley, Queen Mary, University of London

New treatments for chemotherapy-resistant high grade serous ovarian cancer

Dr Matthew Hoare, University of Cambridge

The plasma membrane proteome in senescence as mechanistic, diagnostic and therapeutic target

Dr Marian Burr, University of Cambridge

Understanding molecular mechanisms of leukaemia stem cell self-renewal to identify novel targets for therapy

​* Including grants funded or endorsed by the former Clinical Trials Awards and Advisory Committee.

Late phase clinical trial grants

Dr Shibani Nicum, University College London

ICON9: An international phase 3 randomised trial of cediranib and olaparib maintenance in patients with relapsed platinum sensitive ovarian cancer

 

Sample collection grants

Professor Margaret Knowles and Mr Hugh Mostafid, University of Leeds

CALIBER-T: Prospective sample collection for translational research within the CALIBER trial

Professor Anthony Chalmers, University of Glasgow

PARADIGM-Trans: Sample collection associated with the PARADIGM Trial

Professor Nicholas James and Dr Gerhardt Attard, University College London

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE): A three-stage, multi arm, randomised controlled trial.

 

Feasibility study grants

Professor Carlo Palmieri, University of Liverpool

EMERALD: A Window of opportunity study to assess the biological effects of Enobosarm (Gtx024) in estrogen receptor positive, androgen receptor positive early breast cancer.

 

Clinical trial fellowships

Julia Brown and Jenny Seligmann, University of Leeds

Robert Jones and Ben Fulton, University of Glasgow

Pamela Kearns and Kathryn Herring, University of Birmingham

Mark Middleton and Victoria Woodcock, University of Oxford

Biotherapeutics Project Awards

Professor Aymen Al-Shamkhani, University of Southampton
Evaluation of novel cancer immunotherapeutics designed to deliver optimal T cell co-stimulation.

Professor Alison Banham, University of Oxford
Therapeutic antibodies targeting the tumour vasculature

Dr John Maher, King's College London
Engineering avß6-targeted fourth generation chimeric antigen receptor (CAR) T-cells for immunotherapy of pancreatic ductal adenocarcinoma

Professor John Marshall, Queen Mary, University of London
Development of novel peptide-peptaibol chemotherapeutics for the therapeutic targeting of avß6-expressing cancers

Small Molecule Project Awards

Dr Edmund Kunji, Medical Research Council Centre Cambridge
The mitochondrial pyruvate carrier as a novel target to control metabolic alterations in cancer

Dr Emma Shanks, Cancer Research UK Beatson Institute
Coupling drug repurposing with radiotherapy to improve treatment options and outcome for patients with aggressive oral cancers

Project Awards

Katriina Whitaker, University of Surrey

Understanding socioeconomic differences in help-seeking for breast cancer symptoms in the UK

Julie Walabyeki and Una Macleod, University of Hull

Age linked factors and help seeking behaviour: a qualitative study exploring the effect of older people's fatalistic attitudes towards ill health and dying

Sara Macdonald and Shona Hilton, University of Glasgow

An exploration of the media representation of cancer and its impact on older adults' understanding of cancer risk and help-seeking behaviour

Cristina Renzi, University College London

Missed opportunities for earlier cancer diagnosis along the diagnostic pathway and effect on colorectal cancer diagnosis following emergency presentation: importance of healthcare and patient-related factors

David Weller and Domenica Coxon, University of Edinburgh

Understanding how 'lung cancer symptoms' and 'service' factors drive the decision to seek help from a GP in the Scottish public: a discrete choice experiment

Project Grants

Professor Jane Wardle, University College London

Developing and testing targeted invitation materials to increase uptake of lung cancer screening in communities at high risk of lung cancer 

Dr Kate Brain, University of Cardiff 

Development and pilot evaluation of the Tenovus health check: a targeted cancer awareness intervention for people from deprived communities

Dr Georgios Lyratzopolous, University of Cambridge

What is driving general practice variation in ‘two-week wait’ referrals and use of endoscopy and imaging investigations, and does it matter for cancer outcomes?

Professor Andrew Renehan, University of Manchester

Development of a risk prediction tool for early cancer detection in patients with type 2 diabetes

Dr Peter Murchie, University of Aberdeen

Does place of residence, distance and travelling times from health services within Northeast Scotland influence the diagnostic pathway and outcomes from eight common cancers: analysis of a linked dataset

Drug Development Projects

Professor Janet Brown, University of Sheffield

Exploratory and preclinical development and a Phase I first in human clinical study to evaluate the biological effects of Ad[I/PPT-E1A] Trojan macrophage virotherapy in prostate cancer

 

NAC Preclinical Grants

Dr Karl Butterworth, Queen's University Belfast

Assessment of tumour efficacy and normal tissue toxicity using AZD6738 in combination with radiotherapy for Non-small cell lung cancer

Dr Tatjana Stankovic, University of Birmingham

Assessment of combined chemotherapy and ATR inhibition with AZD6738 in xenograft models of refractory chronic lymphocytic leukaemia (CLL)

Professor Tim Illidge, University of Manchester

Enhancing the efficacy of anti-CD20 mAb (ofatumumab and obinutuzumab) with Innate Immune Modulation with Imprime PGG

Professor R Pedley, University College London

Additional preclinical information study ahead of clinical trial: Comparing efficacy of 177-Lutetium- v 131-Iodine-labeled humanised anti-CEA antibody (huA5B7) when combined with cetuximab in colorectal cancer models.

Dr Thomas Hughes, University of Leeds

Preclinical investigation of HSP inhibitor AT13387 in combination with HER2-targeted therapies in breast cancer models

Professor John Gribben, Queen Mary, University of London

Promoting the therapeutic efficacy of BTK inhibition (Ibrutinib) by combination with antibodies targeting PDL-1/PD-1 mediated inhibitory signalling

Professor Ian Stratford, University of Manchester

Optimising the scheduling of the ATR inhibitor VX803 to maximise the efficacy of radiotherapy (preclinical studies using models of oral and lung cancer).

 

NAC Trial Grants

Professor Anthony Chalmers, University of Glasgow

PARADIGM2: Olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in newly diagnosed glioblastoma stratified by MGMT status: 2 parallel phase I studies. (Jointly funded by Cancer Research UK & The Brain Tumour Charity)

Professor Susan Short, University of Leeds

REOGLIO: A Phase I study of the addition of Reolysin and GMCSF to standard of care first line GBM treatment. (Jointly funded by Cancer Research UK & The Brain Tumour Charity)

Dr Stefan Symeonides, University of Glasgow

A Phase Ib/IIa clinical trial of FAK inhibitor VS6063 in combination with anti-PD1/PDL1 therapy, a dose escalation phase in all solid tumours with expansion cohorts at the optimal dose in  pancreatic cancer, NSCLC or mesothelioma

Dr Maria Hawkins, University of Oxford

CHARIOt: A Phase I trial of ATR inhibitor VX970 and radiotherapy in oesophageal cancer

Professor Hisham Mehanna, University of Birmingham

WISTERIA: A Phase Ib trial of Wee-1 inhibitor AZD1775 combined with cisplatin and radiotherapy in head and neck cancer

Career Development Fellowship

Dr Ross Chapman, Wellcome Trust Centre for Human Genetics

Defining the contribution of 53BP1 to tumour suppression and oncogenesis

Dr Sophie Acton, University College London

Stromal/leukocyte interactions in immunity and tumour progression

Dr Oliver Maddocks, CRUK Beatson Institute

Targeting Tumour Metabolism for Cancer Therapy and Diagnosis

Dr Kevin Myant, University of Edinburgh

The role of dysregulated RNA splicing during colorectal cancer initiation and progression

Career Establishment Award

Dr Trevor Graham, Queen Mary University of London

Quantification of human colorectal cancer evolution: initiation, progression, metastasis and response to treatment

Dr Paul Huang, The Institute of Cancer Research, London

A systems approach for characterising functional pathway dependencies in mutant EGFR lung adenocarcinoma ​

Senior Cancer Research Fellowship

Dr Steven Pollard, University of Edinburgh

The role of SOX and FOX genes in orchestrating transcriptional and epigenetic programs in glioblastoma

Dr Ingo Ringshausen, University of Cambridge

Characterization of signalling pathways underlying bi-directional communications with the microenvironment in B lymphoproliferative diseases

Research Travel Awards

Dr Kirsty Greenow, University of Cambridge

Isolation, culture and analysis of mouse ovarian surface epithelial cells and ovarian stem cells

Dr Karen Evans-Reeves, University of Bath

Knowledge Exchange: Exploring the relationships between tobacco control organisations and their key stakeholders

Dr Gerry Crossan, University of Cambridge

Mechanisms of alcohol induced tumorigenesis

Programme Grants

Bernard Rachet, London School of Hygiene and Tropical Medicine

Cancer survival

Richard Martin and Caroline Relton, University of Bristol

Reducing the burden of cancer: causal risk factors, mechanistic targets and predictive biomarkers

Timothy Key, University of Oxford

The epidemiology and aetiology of high risk prostate cancer

Project Grants

Dr Amanda Cross, Imperial College London

Investigating the aetiology of oesophageal and gastric cancers: the role of hormones

Dr Victoria Coyle, Queen's University Belfast

CHALLENGE UK: A UK arm of the Colon Health And LifeLong Exercise chaNGE trial

Dr Charlotte Coles and Professor Judith Bliss, Institute of Cancer Research

PRIMETIME: Post-operative avoidance of Radiotherapy In Minimal risk womEn: Translational bioMarker ImplemEntation

Professor Stephen Sutton, University of Cambridge

Improving quit rates among smokers in primary care: Pragmatic trial of effectiveness and cost-effectiveness of a tailored web- and text message-based intervention for smoking cessation

Cancer Prevention Fellowship

Alice Forster, University College London

Why are girls from Black and Asian minority ethnic backgrounds less likely to receive the human papillomavirus (HPV) vaccine? Developing and testing a complex psychological intervention to increase informed uptake

Population Research Postdoctoral Fellowship

Samuel Smith, Queen Mary, University of London

Poison or prevention: do cognitive representations of breast cancer chemoprevention affect adherence

Charlene McShane, Queen's University Belfast

Population-based register of monoclonal gammopathy of undetermined significance (MGUS): establishing risk prediction models and investigating patient outcomes

Programme Awards

Dr Adele Fielding, University College London, and Professor Anthony Moorman, Newcastle University​
Personalising therapy for adults with acute lymphoblastic leukaemia(ALL)

Professor Awen Gallimore, Cardiff University
Altering the Tumour Vasculature to Promote Tumour Immunity

Professor Paul Moss, University of Birmingham
From immune suppression to immunotherapy: the function and clinical significance of the immune response to pancreatic cancer

Dr Roger Williams, Medical Research Council Centre Cambridge
Structural mechanisms of regulation of the target of rapamycin complexes

Professor Rebecca Fitzgerald, University of Cambridge
Oesophageal International Cancer Genome Consortium (ICGC) Project (renewal)

Professor Nicholas La Thangue, University of Oxford
The Cancer cell Cycle: Control of pRb and p53 tumour suppressor proteins (renewal)

Professor Stephen Taylor, University of Manchester
Novel approaches to enhance anti-mitotic chemotherapy (renewal)

 

Programme Foundation Awards

Dr Simona Parrinello, Imperial College London
Dissecting glioblastoma invasion: from mutation-driven mechanisms to glioma stem-like cell biology

Dr Adrian Saurin, University of Dundee
Kinase-phosphatase coupling at the kinetochore and the maintenance of chromosomal stability

 

Cancer Immunology Project Awards

Professor Graham Anderson, University of Birmingham
Targeting The Lymphotoxin Beta Receptor To Improve Thymus And Immune Reconstitution Following Stem Cell Transplantation

Professor Silvia Bulfone-Paus, University of Manchester
Modulation of tissue mast cell reactivity in the control of tumour progression

Professor Lucy Dorrell, University of Oxford
Defining the high-risk human papillomavirus (HR-HPV)-specific T cell repertoire in human subjects using a proteome-wide approach

Dr Deena Gibbons, King's College London
The CXCL8-producing T cell: function in health and carcinogenesis

Professor Andrew Mellor, Newcastle University
DNA mediated immune regulation and pain perception at sites of tumourigenesis

 

Multidisciplinary Project Awards

Dr David Atkinson, University College London
Application of inverse problems and modelling to the correction of artefacts in prostate diffusion MRI

Dr Sarah Bohndiek, University of Cambridge
Multidimensional Molecular Imaging for Early Cancer Diagnosis.

Professor Nicola Brown, University of Sheffield
Mechano-biology of the bone metastatic niche in breast cancer

Dr Gilbert Fruhwirth, King's College London
Integrating medical imaging into cancer immunotherapy: Development of clinically traceable CAR and GammaDelta T-cells

Professor Steve Rannard, University of Liverpool
Nanoparticle Interventions for Colorectal Cancer

Project Grants

Olivia Maynard, University of Bristol

Using cognitive neuroscience to improve the effectiveness of tobacco health warnings

Amanda Amos, University of Edinburgh

Young adults' understandings and experiences of e-cigarettes

Adam Crosier, Word of Mouth Research

Cut Films: evaluating a filmmaking and social media peer education intervention to prevent the uptake of smoking among young people

Jamie Brown, University College London

The ‘real-world’ associations between e-cigarette use and smoking cessation: A prospective cohort study

Ann McNeill, King's College London

Secondary analysis of e-cigarette survey data

Funding committees

Successful applicant case studies

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