Recently funded awards

This page features a selection of awards we have supported at recent committee meetings.

Select a funding committee below to see what they have funded recently:

Research Bursaries

Dr Sameena Khan, University of Leicester

Investigating a curcumin-binding protein as a potential druggable target in colorectal cancer stem-like cells

Dr Louise Price, University of Birmingham

PRH/pPRH ratio as a marker of response to cisplatin sensitivity

Dr Kiruthikah Thillai, King’s College London

Does the activity of the PAK-PI3K signalling nexus promote pancreatic cancer tissue invasion?

Clinician Scientist Fellowships

Dr Imran Ahmad, University of Glasgow

Identification and Validation of New Therapeutic Targets in Enzalutamide-Resistant Prostate Cancer

Dr Geoff Higgins, University of Oxford

Elucidation of novel molecular mechanisms of radiation resistance and their application to clinical radiotherapy trials

Dr Michelle Lockley, Queen Mary, University of London

New treatments for chemotherapy-resistant high grade serous ovarian cancer

Dr Matthew Hoare, University of Cambridge

The plasma membrane proteome in senescence as mechanistic, diagnostic and therapeutic target

Dr Marian Burr, University of Cambridge

Understanding molecular mechanisms of leukaemia stem cell self-renewal to identify novel targets for therapy

Late phase clinical trial grants

Professor Johann de Bono and Dr Emma Hall, Institute of Cancer Research

CRUK/11/029: TO-PARP - Trial of Olaparib in Patients with Advanced Castration Resistant Prostate Cancer (AZ/NCRN)

Dr Darren Hargrave, University of Birmingham

CRUK/ 15/ 006: BIOMEDE - Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication

Dr Nicholas Turner and Professor Judith Bliss, Institute of Cancer Research

CRUK/15/010:plasmaMATCH:A multiple parallel cohort,non-randomised,open label,multicentre phaseIIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening

Professor Gordon Cook, University of Leeds

CRUK/ 15/ 008: A phase III study to determine the role of augmented conditioning therapy in second autologous stem cell transplant (ASCT) as consolidation therapy in patients with relapsed multiple myeloma following prior ASCT

Professor David Sebag-Montefiore, University of Leeds

CRUK/ 15/ 007: PLATO - PersonaLising Anal cancer radioTherapy dOse - incorporating ACT 3, ACT 4 and ACT 5 trials

Dr Ana Montes, Guy's and St Thomas' NHS Foundation Trust

CRUK/ 15/ 009: INOVATYON - Phase III international, randomized study of Trabectedin plus Pegylated Liposomal Doxorubicin (PLD) versus Carboplatin plus PLD in patients with relapsed ovarian cancer progressing within 6-12 months of last platinum

 

Sample collection grants

Dr John Bridgewater, University College London

BTC-VBT: Biliary Tract Cancer Studies translational material bank

Professor Terence Jones, University of Liverpool

CRUK/ 13/ 025: Pathos -T: A bioresource collection associated with PATHOS, a Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for human papillomavirus (HPV)-positive oropharyngeal cancer

 

Feasibility study grants

Simon Bach and David Sebag-Montefiore, University of Birmingham

STAR-TREC: Single port TransAnal surgery and Radiotherapy versus Total mesorectal excision for early REctal Cancer

James Larkin and Paul Nathan, Royal Marsden NHS Foundation Trust

PERM: A Randomised Phase II Study Assessing Enhancement of Response to MK3475 by High Dose Palliative Radiotherapy in Patients with Advanced Melanoma

 

Clinical trial fellowships

Julia Brown and Jenny Seligmann, University of Leeds

Robert Jones and Ben Fulton, University of Glasgow

Pamela Kearns and Kathryn Herring, University of Birmingham

Mark Middleton and Victoria Woodcock, University of Oxford

Drug Discovery Project Awards

Adrian Whitehouse, University of Leeds

Next generation antivirals for the treatment of Kaposi’s sarcoma

John Brognard, University of Manchester

LZK: A Novel Target for Therapeutic Intervention in Head and Neck Squamous Cell Carcinoma

Matthew Fuchter and Robert Brown, Imperial College London

Development of dual EZH2/EHMT2 inhibitors for the treatment of solid tumours

Aymen Al-Shamkhani, University of Southampton

Monoclonal antibody targeting of TNF receptor superfamily member 25 to promote anti-tumour immunity.

 

CRUK and Bayer Healthcare co-funded Drug Discovery Project Awards

Anthony Chalmers, University of Glasgow

Identifying and validation of novel targets for overcoming radiation resistance of glioblastoma stem cels under normoxia and hypoxia

Margaret Ashcroft, University of Cambridge

Target identification and mechanism of action studies prior to lead optimization of novel hypoxia/hypoxia inducible factor signalling inhibitors

John Maher, King's College London

Development of gamma delta (gd) T-cell immunotherapy for triple negative breast cancer (TNBC)

Paola Scaffidi, Barbara Nicke and Martin Lange, The Francis Crick Institute

Identification of Epigenetic Mechanisms regulating Cancer Stem Cell Formation and Function

Project Awards

Katriina Whitaker, University of Surrey

Understanding socioeconomic differences in help-seeking for breast cancer symptoms in the UK

Julie Walabyeki and Una Macleod, University of Hull

Age linked factors and help seeking behaviour: a qualitative study exploring the effect of older people's fatalistic attitudes towards ill health and dying

Sara Macdonald and Shona Hilton, University of Glasgow

An exploration of the media representation of cancer and its impact on older adults' understanding of cancer risk and help-seeking behaviour

Cristina Renzi, University College London

Missed opportunities for earlier cancer diagnosis along the diagnostic pathway and effect on colorectal cancer diagnosis following emergency presentation: importance of healthcare and patient-related factors

David Weller and Domenica Coxon, University of Edinburgh

Understanding how 'lung cancer symptoms' and 'service' factors drive the decision to seek help from a GP in the Scottish public: a discrete choice experiment

Project Grants

Professor Jane Wardle, University College London

Developing and testing targeted invitation materials to increase uptake of lung cancer screening in communities at high risk of lung cancer 

Dr Kate Brain, University of Cardiff 

Development and pilot evaluation of the Tenovus health check: a targeted cancer awareness intervention for people from deprived communities

Dr Georgios Lyratzopolous, University of Cambridge

What is driving general practice variation in ‘two-week wait’ referrals and use of endoscopy and imaging investigations, and does it matter for cancer outcomes?

Professor Andrew Renehan, University of Manchester

Development of a risk prediction tool for early cancer detection in patients with type 2 diabetes

Dr Peter Murchie, University of Aberdeen

Does place of residence, distance and travelling times from health services within Northeast Scotland influence the diagnostic pathway and outcomes from eight common cancers: analysis of a linked dataset

NAC Preclinical Grants

Elizabeth Tucker and Louis Chesler, The Institute of Cancer Research

An investigation into the treatment of neuroblastoma with mutations of Anaplastic Lymphoma Kinase (ALK), using LDK378 and LEE011 combination therapy targeting ALK and Cyclin-dependent Kinase (CDK) 4/6, in a preclinical transgenic neuroblastoma model

Caroline Dive, Cancer Research UK Manchester Institute

Assessment of the anti-tumour efficacy and pharmacodynamic effects of combining the Wee1 inhibitor AZD1775 with small cell lung cancer standard of care chemotherapy cisplatin/etoposide or topotecan in unique small cell lung cancer circulating tumour cell derived xenograft models

Caroline Dive, Cancer Research UK Manchester Institute

Assessment of the anti-tumour efficacy and pharmacodynamic effects of combining the Wee1 inhibitor AZD1775 with the Hsp90 inhibitor AT13387 in unique lung cancer circulating tumour cell derived xenograft models

 

NAC Trial Grants

Simon Crabb, University of Southampton

SPIRE: A Phase Ib/IIa clinical trial combining DNA Methyltransferase inhibitor SGI110 with cisplatin and gemcitabine chemotherapy in patients with advanced solid tumours including bladder cancer

Career Development Fellowship

Dr Anna Chambers, University of Bristol

The function of the Irc5 subfamily of chromatin remodelling enzymes in DNA repair

Dr Luis Baena Lopez, University of Oxford

Subcellular regulation and non-apoptotic function of caspases during proliferation and differentiation of stem cells

Dr Jo Waller, University College London

Using behavioural science to maximise the impact of cervical cancer control policies

Dr Carmela De Santo, University of Birmingham

Investigating the immunosuppressive microenvironment created by Acute Myeloid Leukaemia using invariant Natural Killer T cells as a novel therapeutic approach

Dr Jurre Kamphorst, University of Glasgow

The effect of tumour microenvironment on the metabolism of pancreatic cancer cells

Dr Binzhi Qian, University of Edinburgh

The role(s) of macrophages in breast cancer bone metastasis

Dr Elli Papaemmanuil, Wellcome Trust Sanger Institute

Interpret: Clinical and biological implications of acquired somatic mutations in myeloid neoplasms

Career Establishment Award

Dr Walid Khaled, University of Cambridge

Cellular and Molecular Characterisation of Breast Cancer Heterogeneity

Dr Dirk Sieger, University of Edinburgh

In vivo studies of microglia-glioma interactions

Senior Cancer Research Fellowship

Dr Steven Pollard, University of Edinburgh

The role of SOX and FOX genes in orchestrating transcriptional and epigenetic programs in glioblastoma

Dr Ingo Ringshausen, University of Cambridge

Characterization of signalling pathways underlying bi-directional communications with the microenvironment in B lymphoproliferative diseases

Research Travel Awards

Dr Kirsty Greenow, University of Cambridge

Isolation, culture and analysis of mouse ovarian surface epithelial cells and ovarian stem cells

Dr Karen Evans-Reeves, University of Bath

Knowledge Exchange: Exploring the relationships between tobacco control organisations and their key stakeholders

Dr Gerry Crossan, University of Cambridge

Mechanisms of alcohol induced tumorigenesis

Programme Grants

Bernard Rachet, London School of Hygiene and Tropical Medicine

Cancer survival

Richard Martin and Caroline Relton, University of Bristol

Reducing the burden of cancer: causal risk factors, mechanistic targets and predictive biomarkers

Timothy Key, University of Oxford

The epidemiology and aetiology of high risk prostate cancer

Project Grants

Dr Amanda Cross, Imperial College London

Investigating the aetiology of oesophageal and gastric cancers: the role of hormones

Dr Victoria Coyle, Queen's University Belfast

CHALLENGE UK: A UK arm of the Colon Health And LifeLong Exercise chaNGE trial

Dr Charlotte Coles and Professor Judith Bliss, Institute of Cancer Research

PRIMETIME: Post-operative avoidance of Radiotherapy In Minimal risk womEn: Translational bioMarker ImplemEntation

Professor Stephen Sutton, University of Cambridge

Improving quit rates among smokers in primary care: Pragmatic trial of effectiveness and cost-effectiveness of a tailored web- and text message-based intervention for smoking cessation

Population Research Postdoctoral Fellowship

Alice Forster, University College London

Why are girls from Black and Asian minority ethnic backgrounds less likely to receive the human papillomavirus (HPV) vaccine? Developing and testing a complex psychological intervention to increase informed uptake

Samuel Smith, Queen Mary, University of London

Poison or prevention: do cognitive representations of breast cancer chemoprevention affect adherence

Charlene McShane, Queen's University Belfast

Population-based register of monoclonal gammopathy of undetermined significance (MGUS): establishing risk prediction models and investigating patient outcomes

Programme Awards

Professor Malcolm Dunlop, University of Edinburgh

Integrative genomics in colorectal cancer susceptibility: developing risk reducing interventions through understanding biology

Professor Raoul Coombes and Professor Simak Ali, Imperial College London

Transcriptional mechanisms regulating endocrine resistance in breast cancer

Professor Adrian Harris, University of Oxford

Inhibition of novel angiogenic pathways and hypoxic metabolic adaptation for synthetic lethality

Professor Kairbaan Hodivala-Dilke, Queen Mary University of London

Targeting tumour blood vessels to alter angiocrine factors and enhance chemosensitisation

Professor David Lilley, University of Dundee

The nucleic acid structure research group

Professor Shankar Balasubramanian, University of Cambridge

Structure, function and chemical biology of nucleic acids

Professor Stephen Jackson, University of Cambridge

Cellular responses to DNA damage

Professor Gerard Evan, University of Cambridge

Deconstructing MYC oncogenesis

Professor David Glover, University of Cambridge

Supernumerary centrosomes and cancer

Biomarker Project Awards

Professor Vicky Goh and Professor Gary Cook, King's College London

Evaluation of treatment response and resistance in metastatic renal cell cancer using integrated positron emission tomography/magnetic resonance imaging (PET/MRI) with 18F-Fluorodeoxyglucose (FDG)

Professor Kwee Yong and Dr Michael Chapman, University College London

Sequencing approaches to discover markers of response and relapse following Carfilzomib therapy for newly diagnosed patients with multiple myeloma

Mr Stephen Price, University of Cambridge

Predicting sites of treatment failure and tumour recurrence in the invasive margin of glioblastomas (PRaM-GBM Study)

Cancer Immunology Project Awards

Dr Sarah Teichmann and Dr Jacqueline Shields, European Molecular Biology Laboratory

Immune cell-mediated steroidogenesis: a novel mechanism contributing to immune suppression within the tumour microenvironment

Professor Salim Khakoo, University of Southampton

The immunotherapeutic potential of MHC class I-restricted peptide activation of human natural killer cells

Professor Marina Botto and Dr Jessica Strid, Imperial College London

Role of complement in skin tumour immune-surveillance

Professor Gitta Stockinger, Medical Research Council

Functional roles of the aryl hydrocarbon receptor in the intestine- from homeostasis to inflammation and cancerogenesis

Professor Christopher Rudd and Dr Alison Taylor, University of Cambridge

A Novel Pathway that Down-regulates PD-1 Expression for the Treatment of Cancer

Multidisciplinary Project Awards

Professor Sebastien Perrier, Professor Peter Sadler, Professor Francis Lévi and Professor David Rand, University of Warwick

New Generation Clock-Based Cancer Chemotherapy

Dr Anne Kiltie, Professor Boris Vojnovic and Professor Eleanor Stride, University of Oxford

Development of an ultrasound-activated microbubble system on a small animal radiation research platform (SARRP) to treat an orthotopic bladder cancer model with chemoradiation

Dr Dean Barratt and Dr Stephen Pereira, University College London

A Computer-assisted 3D Navigation System for Endoscopic-Ultrasound-Guided Diagnosis and Minimally-invasive Treatment of Pancreatic Lesions

Professor Uwe Oelfke and Professor David Hawkes, Institute of Cancer Research

Automated image processing and treatment planning for real-time MRI guided radiation therapy

Professor Robert Insall and Dr John Mackenzie, Cancer Research UK Beatson Institute

Understanding Cancer Metastasis by Combining Models, Numbers and Molecules

Programme Foundation Awards

Dr Stephen Tait, University of Glasgow

Apoptosis as an oncogenic process: understanding and exploiting its dark-side

Dr Ali Tavassoli, University of Southampton

Identification and development of inhibitors of the KRAS/p110a protein-protein interaction

Professor Edward Tate, Imperial College London

Understanding protein lipidation pathways in cancer: scope, dysregulation and potential for intervention

Dr Robertus de Bruin, University College London

The role of E2F activity in oncogene-induced replication stress

Dr Chris Bakal, Institute of Cancer Research

Understanding how Rho GTP Exchange Factors regulate the cell shape changes underpinning breast cancer metastasis

Project Grants

Olivia Maynard, University of Bristol

Using cognitive neuroscience to improve the effectiveness of tobacco health warnings

Amanda Amos, University of Edinburgh

Young adults' understandings and experiences of e-cigarettes

Adam Crosier, Word of Mouth Research

Cut Films: evaluating a filmmaking and social media peer education intervention to prevent the uptake of smoking among young people

Jamie Brown, University College London

The ‘real-world’ associations between e-cigarette use and smoking cessation: A prospective cohort study

Ann McNeill, King's College London

Secondary analysis of e-cigarette survey data

Funding committees

Successful applicant case studies

Find out how our current grantees successfully applied for funding.

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