Recently funded awards

This page features a selection of investigator-led programmes, projects and fellowships that we have supported through our response-mode grant funding schemes at recent committee meetings.

Select a funding committee below to see what they have funded recently:

Advanced Clinician Scientist Fellowships

Serena Nik-Zainal, Wellcome Trust Sanger Institute

Advancing the understanding and applications of mutational signatures

Andrew Beggs, University of Birmingham

Understanding the molecular basis and consequences of chemoradiosensitivity in rectal cancer in order to improve therapy (MOL-RSRC)

Timothy Underwood, University of Southampton

Cellular interplay in oesophageal cancer

 

Clinician Scientist Fellowships

Jyoti Nangalia, Wellcome Trust Sanger Institute

Evolutionary dynamics of the cancer epigenome in myeloproliferative neoplasms.

Meng Wang, University of Cambridge

Discovering new sources of endogenous DNA damage and their consequences in the haematopoietic lineage

Ross Carruthers, University of Glasgow

Investigating a novel DNA replication phenotype shared by glioblastoma stem cells and neural stem cells and exploiting its therapeutic potential

 

Postdoctoral Research Bursaries

Stuart Robinson, Newcastle University

Characterisation of the innate immune response following ablation of colorectal liver metastases

Filipe Correia Martins, University of Cambridge

Genomic and functional characterization of PTEN loss as a driver event in high-grade serous ovarian carcinoma (HGSOC) - its implications for prognosis and therapeutic response

Biomarker Project Awards

Richard Bryan, University of Birmingham

Amplicon deep sequencing of Urinary DNA for the detection of bladder cancer: AmpseqUr

 

Clinical Trial Fellowships

Harriet Walter and Cassandra Brookes, University of Leicester

Emma Seaford and Pamela Kearns, University of Birmingham

Catherine Hanna and Robert Jones, University of Glasgow

 

Early Phase and Feasibility Study Awards

Carlo Palmieri, University of Liverpool

PEARL - A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer

Grant Stewart, NHS National Services Scotland

NAXIVA: Phase II neoadjuvant study of axitinib for reducing extent of venous tumour thrombus in clear cell renal renal cell cancer with venous invasion

 

Late Phase Clinical Trial Awards

Andrew Davies, University of Southampton

ARGO: A phase II study of Obinutuzumab plus Gemcitabine, Oxaliplatin and Atezolizumab in patients with refractory/relapsed diffuse large B-cell lymphoma who are not candidates for high-dose therapy

Mererid Evans, Terence Jones and Christian Simon, Velindre NHS Trust

Intergroup Study (EORTC-1420-HNCG-ROG) Phase III study assessing the “best of” radiotherapy compared to the “best of” surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0 oropharyngeal carcinoma.

 

Experimental Medicine Awards

Andrew Biankin and Owen Sansom, University of Glasgow

Precision-Panc: a dynamic therapeutic development platform for pancreatic cancer

 

Prospective Sample Collection Awards

Deborah Tweddle, Newcastle University

CCLG Tissue Bank Renewal

Biotherapeutics Project Awards

Alan Parker, Cardiff University

Evaluation of Ad5.3D.A20 - a refined, tumour selective virotherapy

 

Small Molecule Project Awards

Udo Oppermann, University of Oxford

Development of specific inhibitors to validate the methyl-lysine chromatin reader SPIN1 as therapeutic target

Edward James, University of Southampton

Induction of protective anti-tumour T cell responses through modulation of Endoplasmic Reticulum AminoPeptidase 1 activity

Gareth Thomas, University of Southampton

Targeting of cancer associated fibroblasts for oral cancer treatment

Stephen Beers and Mark Cragg, University of Southampton

Validating STING Ligands as Immune Adjuvants for Antibody Therapy

Project Awards

Peter McMeekin, Northern England Strategic Clinical Networks

A systematic comprehensive picture of the extent and nature of GP direct access to diagnostic investigations across the North East and Cumbria

Richard Neal, University of Leeds

Advantage, disadvantages and impacts of different diagnostic pathways in colorectal cancer: routine data analysis and stakeholder interviews

Lucy Brindle and Geraldine Leydon, University of Southampton

Identifying optimal GP-patient communication about direct access tests and referral for investigation of possible cancer

Nicholas Woznitza, Canterbury Christ Church University

Impact of radiographer immediate reporting of chest X-rays from general practice on the lung cancer pathway (radioX)

Katriina Whitaker and Georgia Black, University of Surrey

Using qualitative methods to understand the GP/patient conversation

Drug Development Projects

Mark Middleton, University of Oxford

Preclinical and early clinical development of an IL-2 superkine in advanced solid tumours including lung (NSCLC), melanoma and renal cell carcinoma

 

Preclinical Combinations Grants

Patric Turowski, University College London

Enhancing transcellular transport across the blood-brain barrier to improve efficacy of standard glioblastoma chemotherapy

Rohini Sharma, Imperial College London

Epigenetic modification of somatostatin receptor-2 to improve efficacy of Lutathera in neuroendocrine tumours

Andrew Tutt, The Institute of Cancer Research

Investigating therapeutic targeting of PIM1 kinase in combination with novel and standard of care therapies in preclinical models of triple-negative breast cancer

Bela Wrench, Barts and The London School of Medicine and Dentistry

Targeting arginine deprivation in adult ALL

Sandra Van Schaeybroeck, Queen's University Belfast

Targeting the endoplasmic reticulum stress pathway in BRAF mutant colorectal cancer using the combination of ONC-201 with Cobimetinib or Vemurafenib

Career Development Fellowship

Christopher Tape, University College London

Heterocellular APC Signalling in Colorectal Cancer

Sergio Pérez Acebrón, University College London

Wnt-associated deubiquitination in cancer cells

 

Senior Cancer Research Fellowship

Victoria Sanz-Moreno, King's College London

Investigating Rho-kinase (ROCK) in melanoma progression and therapy response

Programme Grants

Robert West, University College London

Advancing and integrating population and individual approaches to smoking cessation

Eva Morris, University of Leeds

UK Colorectal Cancer Intelligence – Creating the UK COloRECTal cancer Repository (CORECT-R)

 

Project Grants

Tim Coleman, University of Nottingham

The MiQuit study: RCT and meta-analysis testing effectiveness and cost effectiveness of a tailored text message programme for smoking cessation in pregnancy

Douglas Easton and Antonis Antoniou, University of Cambridge

Epidemiological Study of BRCA1 and BRCA2 mutation carriers (EMBRACE)

 

Population Research Postdoctoral Fellowship

Ria Poole, Cardiff University

Tobacco use and pathways into regular smoking among young adults aged 16-25: when, where and how can new public health interventions interrupt ‘social’ smoking trajectories?

Yasmina Okan, University of Leeds

Improving web-based communications about cervical cancer screening using graphs: an interdisciplinary approach

Gemma Taylor, University of Bristol

Acceptability and feasibility of delivering a bespoke smoking cessation treatment in community mental health settings for people with depression

Blanaid Hicks, Queen’s University Belfast

An investigation of biomarkers, lifestyle and pharmacological exposures and risk and progression of renal cell carcinoma

Juliet Usher-Smith, University of Cambridge

Developing a very brief intervention to promote behaviour change for cancer prevention in Primary Care

 

Catalyst Award

Fiona Walter, University of Cambridge, and Willie Hamilton, University of Exeter​

CanTest- Cancer diagnostic testing in primary care: a paradigm shift for cancer diagnosis

 

 

Programme Awards

Derek Mann, Helen Reeves and Owen Sansom, Newcastle University

Towards targeting neutrophils in hepatocellular carcinoma

Fiona Watt, King's College London

An integrated analysis of oral squamous cell carcinoma development and progression

Chris Jones, The Institute of Cancer Research

Targeting subclonal diversity and co-operation in paediatric glioblastoma and diffuse intrinsic pontine glioma

Graham Packham, University of Southampton

B-cell receptor signalling in B-cell malignancies: Identifying strategies for optimal therapeutic intervention based on common and distinct responses

Dale Wigley, Imperial College London

Structural and mechanistic studies of proteins involved in human DNA double-strand break repair (renewal)

Ketan Patel, Medical Research Council Centre - Cambridge

Understanding how alcohol and endogenous aldehydes promote carcinogenesis (renewal)

Kevin Harrington, The Institute of Cancer Research

Optimising Radiation Therapy in Head and Neck Cancers Using Functional Image-Guided Radiotherapy (renewal)

Richard Bayliss, University of Leeds

From kinase molecular mechanisms towards new cancer therapeutics (renewal)

Grant Stewart, University of Birmingham

Characterising novel regulators of the PI-3-kinase-like kinase-dependent DNA damage response and their role in preventing human disease and cancer (renewal)

Josef Vormoor and Olaf Heidenreich, Newcastle University

Childhood Acute Lymphoblastic Leukaemia - targeting novel mechanisms of clonal survival and expansion (renewal)

Steven Clifford, Daniel Williamson and Simon Bailey, Newcastle University

Biomarker-driven individualisation of medulloblastoma therapy (renewal)

Jacqueline Shaw and Charles Coombes, University of Leicester

Utilising Cancer Genetic Evolution for Early Detection and Monitoring of Breast Cancer (renewal)

 

Programme Foundation Awards

Emma Harris, The Institute of Cancer Research

Multi-parametric ultrasound imaging for assessment of tumour response to radiotherapy

Katrin Ottersbach, University of Edinburgh

Understanding the origin and pathogenesis of MLL-AF4-associated infant leukaemia

 

Cancer Immunology Project Awards

Pierre Guermonprez, King's College London

Functional significance of the GM-CSF secreted by tumours for anti-tumoral T cell responses

Rose Zamoyska, University of Edinburgh

Genetic manipulation of Human T cells for use in adoptive T cell therapy

Robert Salmond, University of Leeds

Manipulating T cell signalling to improve anti-tumour immunity

Paul Klenerman, University of Oxford

Harnessing CD8 T cell memory inflation to control cancer

Salah Mansour, University of Southampton

A new class of tumour-associated lipid antigens for recognition by CD1c-restricted T cells

 

Multidisciplinary Project Awards

Helen Mulvana and Susan Moug, University of Glasgow

Development of non-ionising and non-invasive, personalised colorectal cancer staging using novel multimodal contrast agents and magnetomotive ultrasound imaging

Buzz Baum, University College London

The quantitative analysis of signalling dynamics in breast cancer : an interdisciplinary approach

Guillaume Salbreux and Guillaume Charras, The Francis Crick Institute

Understanding the biophysical basis of cellular shape change during mitosis

Bon-Kyoung Koo and Benjamin Simons, University of Cambridge

Tracing the cellular basis of cancer development

Matthew Fuchter, Peter DiMaggio and Hugh Brady, Imperial College London

Profiling the ‘Methylome’ Targets of the Histone Lysine Methyltransferases: DOT1L

Project Grants

Jason Hughes, University of Leicester

Adolescent vaping 'careers': a qualitative study of the usage trajectories of 16–18-year-old E-cigarette users in England

Crawford Moodie and Olivia Maynard, University of Stirling

Adult smokers’ perceptions of pack inserts with positive messaging about cessation: A naturalistic study

Peter Hajek, Queen Mary, University of London

Developmental trajectory of dual users of e-cigarettes and conventional cigarettes

Frances Thirlway, University of York

E-cigarettes, health inequalities and smoking cessation: a community study of take-up and market evolution in two high smoking prevalence areas of the North of England.

Jo Brett, Oxford Brookes University

Knowledge, attitudes and current practice of health professionals regarding the use of e-cigarettes and other smoking cessation interventions in cancer survivors

Timea Partos, King's College London

Longitudinal survey on e-cigarette use and smoking behaviour: 5th wave

Catherine Best and Sally Haw, University of Stirling

Longitudinal trends in national smoking prevalence and e-cigarette use in the European Union

Rachna Begh, University of Oxford

Perceptions of GPs and nurses on the role of e-cigarettes for harm reduction and smoking cessation in general practice

Rachna Begh, University of Oxford

Raising the topic of smoking cessation in general practice: a conversation analysis of GP consultations on smoking

Kamran Siddiqi, University of York

Smokeless tobacco control in the UK: A supply chain analysis to inform policy

Tessa Langley, University of Nottingham

Study of emissions, toxicity, sales and marketing data for tobacco and electronic cigarette products on the UK market

Charlotte Smith, University of Leicester

The regulation of e-cigarettes in and around organisational lives

Amanda Farley, University of Birmingham

Understanding the nature and drivers of dual use of electronic and tobacco cigarettes

More facts and figures about our research funding

Facts and figures about our research funding

Find out more about how and where we supported research in the last year with our interactive map and infographics.

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