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Afatinib (Giotrif)

Find out what afatinib is, how you have it and other important information about taking afatinib.

Afatinib (pronounced aff-a-tin-ib) is a cancer treatment drug and is also known by its brand name Giotrif (pronounced jee-oh-triff).

It is a treatment for lung cancer.

How it works

Afatinib is a type of cancer growth blocker called a protein tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that stimulate cells to grow. Afatinib blocks tyrosine kinases and also blocks epidermal growth factor receptor proteins in cancer cells. So afatinib is also called an EGFR-TK inhibitor.

Your doctor will check your cancer cells to see if they have these receptors. Cancers that have these receptors are called EGFR-TK positive.

How you have it

Afatinib is a tablet. You swallow it whole with a glass of water.

You can dissolve afatinib in a glass of still water if you have difficulty swallowing tablets. Don’t use any other type of liquid. Drop the tablet into the water without crushing it. Stir it occasionally for up to 15 minutes until the tablet has broken up into very small particles. Drink it straight away. Fill the glass again with water and drink it to make sure you take the whole dose.

When you have it

You take afatinib once a day on an empty stomach. You take them at least one hour before eating or 3 hours after eating.

You usually carry on taking it for as long as it is still working, unless the side effects get too bad.

You must take tablets and capsules according to the instructions your doctor or pharmacist gives you.

Whether you have a full or empty stomach can affect how much of a drug gets into your bloodstream.

You should take the right dose, not more or less.

Never stop taking a cancer drug without talking to your specialist first.

Tests during treatment

You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Pregnancy and contraception

This drug may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug and for at least a month afterwards.

Talk to your doctor or nurse about effective contraception before starting treatment.

Fertility

We don’t know how this treatment might affect fertility. You may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.

Some men might be able to store sperm before starting treatment. Some women might be able to store eggs or embryos before treatment.

Breastfeeding

Don’t breastfeed during this treatment because the drug may come through in your breast milk.

Treatment for other conditions

Always tell other doctors, nurses or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Immunisations

Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and Zostavax (shingles vaccine).

You can:

  • have other vaccines, but they might not give you as much protection as usual
  • have the flu vaccine
  • be in contact with other people who've had live vaccines as injections

Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, you mustn't change their nappies for 2 weeks after their vaccination.

You also need to avoid anyone who has had oral polio or typhoid vaccination recently.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help

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