Early Detection OHSU Project Award

About this scheme

Key information

Career level
Early career researcher
Mid-career researcher
Established independent researcher
Non-clinical researcher
Clinician
Research area
Biomarker research
Clinical trials
Pre-clinical research
Imaging research
Statistics and methodology
Cancer biology
Final submission
Committee review
Funding period
Up to 2 years
Funding amount
Up to £250,000 plus $300,000 for OHSU-based researchers
Funds new and existing collaborations in early detection between researchers in the UK and at Oregon Health and Sciences University (OHSU).

Each application must have a lead applicant from both a UK institution and OHSU.

You should:

  • Have at least three years’ postdoctoral experience or equivalent
  • Be scientists, clinicians or healthcare workers in UK universities, medical schools, hospitals, CRUK Institutes or other research institutions, or at OHSU

Scientific remit

Early detection (EDx) research seeks to identify cancer or pre-cancerous states at the earliest possible point at which an intervention might be made. such signals will detect, but may also underpin prognosis/stratification/prediction of response to therapy and prevention. EDx projects will support discovery and translational/clinical research which is mindful of the clinical and population context.

EDx operates across the full pathway of disease development: detecting events from the earliest changes suggesting initiation, to dysregulated growth, promotion to pre-neoplastic states/lesions, malignant conversion, and tumour progression. Each of these stages provide an opportunity to detect a shift in state, and ultimately to intervene to improve survival. Early detection can also be applied post-therapy, to detect recurrence at the earliest possible point.

The remit of these awards includes:

  • Biological research underpinning early detection and biomarker discovery and validation
  • Human-based EDx discovery research
  • Epidemiology and risk stratification for EDx (to inform populations for targeted research or screening)
  • Data and computation-driven approaches to EDx
  • Development and utilization of preclinical EDx model systems
  • EDx technology development
  • Translational and clinical EDx research

Your project may focus on any of these research areas, or any combination of them. Your proposal should consider line-of-sight to clinical or population impact.  

EDx projects will drive transatlantic collaboration and facilitate early detection knowledge exchange. We want to bring together outstanding teams to further establish a research community around this nascent field.

Looking for a collaborator?

You can either tell other early detection researchers what expertise you're looking to work with using our collaboration matcher or contact early.detection@cancer.org.uk with details of your  project and OHSU will suggest a collaborator within their organisation. 

Awarded once annually and are typically made up to £250K for UK-based researchers plus $300,000 for OHSU-based researchers for up to 2 years, and may be used to fund:

  • Postdoctoral researchers
  • Technical staff
  • Associated running expenses
  • Equipment up to £5,000 / $5,000

Cancer Research UK contact details

Dr Alexis Webb

Dr Alexis Webb

Senior Research Funding Manager

earlydetection@cancer.org.uk

Tel: +44 (0) 20 3469 5232

How to apply to this scheme

Overview of the application process

  1. CRUK applicants should contact the Early Detection team to open an application. 
  2. OHSU applicants must email CEDARprojects@ohsu.edu to request a letter of support from CEDAR Senior Management. This letter will be used to verify that the project scope fits within the CEDAR’s remit of early detection and that the OHSU applicants meet eligibility requirements. Please include the email subject: “OHSU-CRUK Letter of Support”.
  3. Submit an application.
  4. Your application will be considered by the CRUK Early Detection Research Committee.

.All applications must be made online through our online grant management system  eGMS, and the final application must be approved online by the lead applicant host institution via the eGMS system.

Deadline: 20 June 2019

Committee Review: November 2018

Before you begin your application

Please ensure you:

Whichever stage of research the proposal addresses, from discovery to applied, proposals should have a clear line-of-sight to clinical/population impact, and should articulate this pathway and the evidence that will be required to advance along it.  Implementation of this clinical line of sight may be either during or downstream of the proposed work (it is not mandatory for all proposals to include a direct translational component).  Appropriate involvement of clinical/population expertise to ensure this line-of-sight is encouraged.

While therapeutic development is not covered by the EDx programme (being funded through other CRUK mechanisms), EDx research should acknowledge and account for the importance of therapeutics as context, and to help inform understanding of when surveillance is more appropriate than intervention.

Teams of applicants should be assembled to adequately consider these issues, involving collaboration between e.g. biologists, clinical researchers, engineers/physical scientists, maths/stats/computation expertise, population scientists and industry (as appropriate to the proposal).  Multidisciplinary, overseas and industrial collaboration is encouraged when appropriate to the science proposed, and where clear added value can be articulated.

Applicants are encouraged to make use of existing cohorts and tissue banks as resources for EDx research.

Applications will be judged based on:

  • Scientific excellence and innovation
  • Clear articulation of the challenge to be addressed
  • Cancer early detection relevance
  • Clarity of line-of-sight to clinical/population impact
  • Team composition: are the requisite skillsets to deliver the proposed work and achieve impact in place? Do any collaborations between disciplines, institutions or with industry add value to the project?
  • Is the required infrastructure in place to deliver the proposed research?

Cancer Research UK contact details

Dr Alexis Webb

Dr Alexis Webb

Senior Research Funding Manager

earlydetection@cancer.org.uk

Tel: +44 (0) 20 3469 5232

Similar funding schemes

Early Detection OHSU Spark Award

Seed funding for research in collaboration with Oregon Health and Sciences University scientists to support development of new partnerships and novel lines of enquiry 

Early Detection Project Awards

Support and encourage specific research projects that aim to have a significant impact on how and when cancer is detected.

 

Early Detection Programme Awards

Support and encourage established researchers to perform large, integrated and renewable research programmes which have the potential to transform early cancer detection.

More funding opportunities like this

We have a range of funding opportunities catering for a broad research community at all career stages and in any research field which can impact on earlier detection and diagnosis of cancer.

Find a collaborator

Looking for a collaborator for this award?

Submit your details and search for a potential partner using our Early Detection Collaboration Matcher.

Early Detection Conference

Our annual Early Detection of Cancer Conference, held in partnership with the OHSU Knight Cancer Institute, provides the perfect opportunity to network and build new collaborations with experts from many different disciplines.

In partnership with

OHSU Knight Cancer Institute

Our transatlantic partnership with the Knight Cancer Institute is part of a long-term commitment to breaking down the barriers that limit progress in the early detection field.