Discovery Research Committee awards

Discovery Programme Awards

May 2025

Optimisation of anti-cancer CD4+ T cell responses through molecularly-informed modification of HLA class II antigens

Professor Andrew Godkin

Cardiff University

Professor Awen Gallimore

Cardiff University

Molecular mechanisms of the β-catenin destruction complex in normal signalling and cancer

Professor Sebastian Guettler

Institute of Cancer Research

G-quadruplex DNA mechanisms and cancer

Professor Sir Shankar Balasubramanian

University of Cambridge

Enhancing immune surveillance and targeting senescence to treat high-grade serous ovarian carcinoma

Professor Jesus Gil

Imperial College London

Defining mechanisms of T cell dysfunction in liver metastases of colorectal cancer

Professor Leonard Seymour

University of Oxford

Dr Kerry Fisher

University of Oxford

Dr Alex Gordon-Weeks

University of Oxford

November 2024

Gene-environment initiated disease progression in myeloproliferative neoplasm

Professor Adam Mead

University of Oxford

Targeting the stem-like maintenance programme of Treg cells to reverse immune suppression and immunotherapy resistance in cancer

Professor Rahul Raychaudhuri

University of Cambridge

Advancing MRI biomarkers of the tumour microenvironment for patient benefit

Professor Simon Robinson

Institute of Cancer Research

Outcompeting oncogenesis: oesophageal cancer prevention by manipulating mutant fitness

Professor Philip Jones

Wellcome Sanger Institute

Nascent DNA strand maturation in human cells and its targeting by inhibitors of poly(ADP-Ribose) metabolism

Professor Keith Caldecott

University of Sussex

PI3K in cancer biology and therapy

Professor Bart Vanhaesebroeck

University College London

The role of RNA structure and modification in cancer

Professor Eric Miska

University of Cambridge

Discovery Programme Foundation Awards

June 2025

Application of a molecular and cellular imaging toolbox to develop and interrogate receptor-targeted cancer treatments

Dr Michelle Ma

King's College London

Leveraging RNA splicing inhibition to enhance efficacy of immunotherapies in immune-cold colorectal cancer

Dr Kevin Myant

University of Edinburgh

Tissue specificity of cell cycle dysregulation in cancer

Dr Alexis Barr

Imperial College London

Stem cell signatures of mutational order in colorectal cancer

Professor Simon Buczacki

University of Oxford

November 2024

T cells under pressure

Dr Robert Köchl

King’s College London

Professor Marco Fritzsche

University of Oxford

Elucidating the role of chromosomal copy number variants in neuroblastoma

Dr Anestis Tsakiridis

University of Sheffield

Understanding and exploiting ribosome biogenesis dysregulation in cancer

Dr Faraz Mardakheh

University of Oxford

Discovering and targeting the wider super-enhancer network of acute lymphoblastic leukaemia

Dr Lisa Russell

Newcastle University

Multidisciplinary Project Awards

This funding scheme is now closed.

June 2025

Investigating cell plasticity via spatiotemporal epigenetic perturbation

Dr Marco Di Antonio

Imperial College London

Professor Luca Magnani

Institute of Cancer Research

November 2024

Glymphatic brain clearance: A novel therapeutic target in glioblastoma

Professor Mark Lythgoe

University College London

Dr Martin Pule

University College London

Cancer Immunology Project Awards

This funding scheme is now closed.

November 2024

Transcriptome instability as a determinant of renal cancer immunotherapy outcomes

Professor Dimitris Lagos

University of York