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Risks and causes

We don’t know what causes most mouth or oropharyngeal cancers. But there are some factors that can increase your risk of developing it.

Having any of these risk factors does not mean that you will definitely develop cancer.

Smoking

Smoking tobacco (cigarettes, pipes, cigars) increases your risk of developing mouth and oropharyngeal cancer. Research suggests that more than 60 out of 100 (more than 60%) of mouth and oropharyngeal cancers in the UK are caused by smoking.

There is some evidence that people exposed to second hand smoke (passive smoking) at home or in the workplace may have a small increase in their risk of mouth and oropharyngeal cancer. 

Alcohol

Drinking alcohol increases your risk of mouth and oropharyngeal cancer. Research shows around 30 out of 100 (30%) of mouth and oropharyngeal cancers are caused by drinking alcohol.

Smoking and drinking together further increases the risk of cancer more than either by itself.

UK guidelines recommend a maximum of 14 units of alcohol a week for both men and women. 

Chewing tobacco or betel quid

Smokeless tobacco, including chewing tobacco, such as betel quid (gutkha) or paan is known to cause mouth and orpharyngeal cancer. It is not a safe alternative to cigarettes. In the UK, it is often popular with South Asian communities. 

Diet

A diet low in fruit and vegetables may increase your risk of mouth and orpharyngeal cancer. This might be due to a lack of vitamins and minerals. A balanced diet ususaly means you are getting enough vitamins and minerals. 

Human papilloma virus (HPV)

The human papilloma virus (HPV) is a type of virus that infects the skin and the cells lining body cavities. For most people, HPV causes no harm and gets better on it's own. You don't catch cancers like an infection. But the virus can cause changes in the mouth and throat making them more likely to become cancerous in the future. 

HPV spreads through close skin to skin contact, usually during sexual activity. It is very common. Only a very small percentage of people with HPV develop mouth or oropharyngeal cancer. 

The risk of HPV in the mouth and throat is linked to certain sexual behaviours, such as oral sex, and having a higher number of sexual partners. 

Weak immune system

Your body's immune system fights infection. Some illnesses and medication can weaken your immune system. Research shows an increased risk of mouth cancer if you are:

  • having treatment for HIV or AIDS
  • taking medicines to suppress your immune system after an organ transplant

Sunlight and sunbeds

Too muich ultraviolet (UV) radiation from the sun or sunbeds is the main cause of skin cancer. Skin cancers are relatively common on the head and neck as these areas are often exposed to UV radiation. Skin cancer can develop on the lip.

Previous cancer

People who have had a mouth or orpharyngeal cancer have an increased risk of getting a second one. 

People who have the following cancers are also at increased risk of mouth and orpharyngeal cancer:

  • cancer of the food pipe (oesophagus) 
  • squamous cell skin cancer 
  • cervical cancer 
  • penile cancer 
  • anal cancer 

Family history

Research shows a slight increase in risk of mouth and oropharyngeal cancer if you have a close relative (parent, sibling, or child) who has had mouth cancer. Further research is needed to understand why this is. 

Mouth conditions

Changes can happen in the cells in the lining of the mouth. They can appear as red or white patches in the mouth. The red patches are called erythroplakia. White patches are called leukoplakia.

In some people, these conditions may develop into cancer over some years. Doctors call these conditions precancerous. 

Dentists can spot these patches during your dental check ups so it is important to go for regular dental appointments. 

Genetic conditions

People with certain conditions caused by inherited cell changes (mutations) have an increased risk of mouth and orpharyngeal cancer. These conditions include:

  • fanconi anaemia (a genetic condition affecting the bone marrow)
  • dyskeratosis congenita (a condition causing changes to bone marrow, skin or fingernails) 

Blood pressure drug (hydrochlorothiazide)

Hydrochlorothiazide is a drug to treat high blood pressure (hypertension). A side effect is increased sensitivity to sunlight (photo sensitvity). A small study showed this medicine might lead to an increased risk of developing lip cancer. 

For detailed information on mouth or orpharyngeal cancer risks and causes

Last reviewed: 
20 Aug 2018
  • Parkin DM. Cancers attributable to consumption of alcohol in the UK in 2010(link is external).

    Br J Cancer 2011; 105 (S2):S14-S18   

  • International Agency for Research on Cancer. List of Classifications by cancer sites with sufficient or limited evidence in humans,

    Volumes 1 to 117*(link is external). Accessed January 2017

  • High-Risk Human Papillomavirus in Oral Cancer: Clinical Implications

    S Yete et al

    Oncology. 2018;94(3):133-141

  • Understanding personal risk of oropharyngeal cancer: risk-groups for oncogenic oral HPVinfection and oropharyngeal cancer

    G De Souza et al

    Annals of oncology 2017 Dec 1;28(12):3065-3069

  • Bosetti C, Scelo G, Chuang SC. High constant incidence rates of second primary cancers of the head and neck: a pooled analysis of 13 cancer registries(link is external).

    International Journal of Cancer 2011;129(1):173-9

  • The information on this page is based on literature searches and specialist checking. We used many references and there are too many to list here. If you need additional references for this information please contact patientinformation@cancer.org.uk with details of the particular risk or cause you are interested in.

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