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Hairy cell leukaemia

Symptoms of hairy cell leukaemia

Hairy cell leukaemia is a rare type of chronic leukaemia. Symptoms can be mild at first and get worse slowly. Some people don't have any symptoms, but it gets picked up through a blood test.

Frequent infections

You might pick up infections more easily as the numbers of abnormal white blood cells rise. This is because abnormal white blood cells are not as good at fighting infection as healthy ones.

You might have very high temperatures if you have an uncontrolled infection.

Tiredness and breathlessness

You might feel tired and short of breath if you have a low level of ​​ (anaemia). This could happen if your bone marrow becomes crowded by abnormal white blood cells. So your bone marrow can’t produce enough red blood cells. Red blood cells help to carry oxygen around the body.

Bleeding or bruising easily

The extra white blood cells take up more space in the bone marrow as their numbers rise. So there's not enough room for the bone marrow to make platelets. Platelets normally help the blood to clot, so you might have:

  • nosebleeds

  • unexplained bruising

  • unusually heavy periods

Swelling and pain in your tummy (abdomen)

The spleen is an organ on the left of your body, just under your ribs. It is part of the lymphatic system. Hairy cell leukaemia can cause your spleen to be bigger than normal. This is called an enlarged spleen.

Your doctor might be able to feel your enlarged spleen. Your abdomen might be uncomfortable or painful. 

Diagram showing the position of the spleen.

Leukaemia cells building up in the liver can also cause tummy (abdominal) swelling.

Weight loss

Hairy cell leukaemia itself uses up energy that your body would otherwise use or store. So you might lose weight, even if you're eating normally.

An enlarged spleen may also contribute to weight loss by squashing your stomach. This can make you feel full more quickly than usual, so you eat less than you normally would.

Get tips on seeing your GP about your symptoms

Last reviewed: 24 Sept 2024

Next review due: 24 Sept 2027

Diagnosing hairy cell leukaemia

You usually start by seeing your GP and they might refer you to a specialist and organise tests. Find out more about tests and screening for hairy cell leukaemia.

Stages of hairy cell leukaemia

The stage means how far your leukaemia has developed. There is no widely agreed staging system for hairy cell leukaemia.

Treatment for hairy cell leukaemia

There are different treatments for hairy cell leukaemia. You might have one treatment, or a combination. The main treatment is chemotherapy.

What is hairy cell leukaemia?

Hairy cell leukaemia (HCL) is a rare type of chronic leukaemia. It develops slowly from white cells called B lymphocytes.

Hairy cell leukaemia main page

Hairy cell leukaemia (HCL) is a rare type of chronic leukaemia. It develops slowly from white blood cells called B lymphocytes. Find out about this type of leukaemia.

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