Managing high calcium

Having high calcium levels is called hypercalcaemia. It is a serious condition. Your doctor will need to assess you, so you get the right diagnosis and treatment.

Diagnosing high calcium

Your doctor might examine you. They will ask about your symptoms, how long you have had them and whether you:

  • are feeling or being sick
  • feel thirsty
  • have lost your appetite
  • feel more tired than usual
  • feel confused
  • have pain

These questions might seem like a lot to deal with if you are not feeling very well at the time. But it is very important that your doctor takes the time to get all the information. Your family and friends might be able to answer questions if you are in too much pain or feeling too tired or sick.

Your doctor will measure your calcium levels with a blood test. You might also have other tests and investigations to see how well your kidneys are working. You may have an ECG test to see if your heart is affected by the high calcium level. You will need treatment if the test results show that you have high levels of calcium in your blood.

Can you prevent high calcium?

Unfortunately high calcium is a possible risk associated with advanced cancer. It is not really possible to prevent it from happening.

Recognising the symptoms of high blood calcium is important so that you can ask your doctor for help as soon as possible. 

Treating high calcium

The aims of treatment for high blood calcium are to lower the levels and relieve the symptoms. You might need to spend some time in hospital to get your calcium levels down.

You might have one or more of the following treatments. 


Fluids through a drip help flush the extra calcium out of your system. Drinking plenty of fluid will help too if you can manage it.


You might have steroids to help reduce your calcium levels. You might have steroids as tablets or into your bloodstream as an injection.


Bisphosphonates (bis-fos-fon-ates) are very effective drugs for helping to get your calcium levels down. You can have some of these drugs through a drip into a vein, but others come as tablets. Which type you need depends on how high your calcium levels are. Your doctor will decide on the best treatment for you.

Bisphosphonates can also help to reduce pain from cancer that has spread to the bone. And they can help to stop damaged bones breaking. You might have bisphosphonate tablets to take home to stop the calcium building up in your blood again.

Bisphosphonates can sometimes make your calcium level go too low (hypocalcaemia). This should be picked up by blood tests. But it is also worth being aware of the possible symptoms of low calcium levels. For example, numbness or tingling in the feet and hands, and around the mouth.


You might have another drug called calcitonin to help stop the breakdown of bone. You have this drug as an injection.


Denosumab (pronounced den-oh-sue-mab) is a type of targeted therapy called a monoclonal antibody. It is made in the laboratory to recognise and find specific proteins on the outside of some cells. Denosumab is also known by its brand names, Xgeva and Prolia.

This drug is used to prevent fractures and other cancer related bone problems. It is recommended in adults with some types of cancer that has spread to the bones.

You might have denosumab if you have high calcium and bisphosphonates have not brought your calcium levels down. Or you might have it if you are unable to have bisphosphonates for a medical reason.

Other drugs

You might also have drugs to help relieve high calcium symptoms, such as sickness, constipation, pain or confusion.

Your doctor might suggest you stop taking other medications if they could be making your hypercalcaemia worse. These include:

  • calcium supplements
  • lithium (a type of mood stabiliser)
  • some medicines for heartburn and acid reflux
  • some water tablets (diuretics)

What treatment will I have?

The type of treatment you have depends on how high your calcium levels are and how severe your symptoms are.

For example, you have urgent treatment with fluids and bisphosphonate drugs if you have moderate to severe high calcium, or severe symptoms. You still need treatment, but less urgently, if it is mild high calcium. You might just need bisphosphonate treatment if you are able to drink plenty of fluids.

Treatment relieves some symptoms more quickly than others. For example, sickness, constipation and thirst are much easier to relieve than tiredness and loss of appetite.

It will probably not be possible to control high calcium permanently if your cancer is very advanced and you are in the final days or weeks of life. But your doctors will do all they can to help make you as comfortable as possible.

Follow up

Once your blood calcium levels go back to normal, your doctor will want to keep a close eye on you. You have regular blood and urine tests to make sure the treatment is still working.

It is very important that you see your doctor as soon as possible if you feel the symptoms of high calcium are coming back. Even if something else is causing your symptoms, it is better to see your doctor to find out for sure.

You might worry about eating foods that contain calcium if you have high calcium or think you may be at risk of it. But cutting down on these foods will not help high calcium that is caused by cancer. It will not make any difference to your calcium levels.

Do talk to your doctor or nurse if you are concerned about your diet. And make sure you check with your doctor before taking any vitamin or mineral supplements.

This page is due for review. We will update this as soon as possible.

Last reviewed: 
27 Nov 2018
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