Risks and causes of chronic myeloid leukaemia (CML)

We don’t know what causes most cases of chronic myeloid leukaemia (CML). But we do know that exposure to radiation can increase your risk of developing CML.

Having this risk factor doesn't mean that you will definitely develop cancer.

What is a risk factor?

Anything that can increase your risk of getting a disease is called a risk factor.

Different cancers have different risk factors.­ Having one or more of these risk factors doesn't mean you will definitely get that cancer.

High energy radiation (ionising radiation)

Exposure to high energy radiation Open a glossary item (x-rays or gamma rays) is linked to a very small increased risk of developing acute leukaemia Open a glossary item. CML is one type of acute leukaemia. This could be through medical tests such as x-rays and CT scans Open a glossary item, or having radiotherapy Open a glossary item for cancer.

The health risks of radiation from tests such as x-rays are generally very low and it is important you have these tests to get the right diagnosis and treatment. Doctors keep your exposure to radiation as low as possible and only do them when they are necessary.

Although having radiotherapy in the past has been linked with an increased risk of cancer, the risk is balanced by the need to treat the original cancer.

Are there other causes?

Stories about possible cancer causes are often in the media and it can be hard to know what’s true and what’s not. You may have heard of something that isn’t included here. This is because we only include a risk factor in this information if it is supported by good quality evidence.

Reducing your risk

There are ways you can reduce your risk of cancer.

  • List of Classifications by cancer sites with sufficient or limited evidence in humans, IARC Monographs Volumes 1 to 138
    The Internal Agency for Research on Cancer (IARC), last updated March 2025
    Accessed May 2025

  • Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKERS): an international cohort study
    K Leuraud and others
    Lancet Haematology, 2015. Volume 2, Pages e276 to e281

  • Radiation exposure and leukaemia risk among cohorts of persons exposed to low and moderate doses of external ionising radiation in childhood
    M P Little and others
    British Journal of Cancer, August 2023. Volume 129, Pages 1152 to 1165

  • The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015
    K Brown and others
    British Journal of Cancer, 2018. Vol 118, pages 1130 -1141

  • Epidemiological patterns of leukaemia in 184 countries: a population-based study
    A Miranda-Filho and others
    The Lancet Haematology, January 2018. Volume 5, Pages e14 - e24

Last reviewed: 
19 Jun 2025
Next review due: 
19 Jun 2028

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