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Z-DEX

Read about Z-DEX, a chemotherapy treatment that is also called I-DEX, and its possible side effects.

What it is

Z-DEX is a treatment for myeloma. Sometimes this drug combination is called I-DEX. It includes the drugs:

  • Idarubicin (Zavedos) – a chemotherapy drug
  • Dexamethasone – a steroid

How you have it

You usually have Z-DEX chemotherapy as cycles of treatment. Each cycle lasts 3 weeks. Depending on your needs, you may have up to 6 cycles, taking 4 to 5 months in total.

Idarubicin comes as capsules. Swallow them whole with a glass of water. You can take them with a meal.

Dexamethasone comes as tablets or as a liquid that you swallow. Take it after a meal, or with milk, because it can irritate your stomach lining. It can also make it difficult to sleep but taking it early in the day can reduce this effect.

For the first 4 days of each treatment cycle you take both idarubicin and dexamethasone once a day. Then you have no treatment for 17 days. You then start the next treatment cycle.

Taking your tablets or capsules

You must take tablets and capsules according to the instructions your doctor or pharmacist gives you.

Whether you have a full or empty stomach can affect how much of a drug gets into your bloodstream.

You should take the right dose, not more or less.

Talk to your specialist or advice line before you stop taking a cancer drug.

Tests

You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Pregnancy and contraception

This treatment might harm a baby developing in the womb. It is important not to become pregnant or father a child while you're having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.

Breastfeeding

Don’t breastfeed during this treatment because the drug may come through into your breast milk.

Blood clots

You are more at risk of developing a blood clot during treatment. Drink plenty of fluids and keep moving to help prevent clots.

Treatment for other conditions

Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Immunisations

Having immunisations 

Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and the shingles vaccine (Zostavax).

You can:

  • have other vaccines, but they might not give you as much protection as usual
  • have the flu vaccine (as an injection)

Contact with others who have had immunisations 

You can be in contact with other people who have had live vaccines as injections. Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as the oral typhoid vaccine.

If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray. This is for 2 weeks following their vaccination.

Babies have the live rotavirus vaccine. The virus is in the baby’s poo for about 2 weeks and could make you ill if your immunity is low. Get someone else to change their nappies during this time if you can. If this isn't possible, wash your hands well after changing their nappy.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Last reviewed: 
14 Jul 2015
  • British National Formulary

    Accessed July 2015

  • Electronic Medicines Compendium

    Accessed July 2015

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