ESHAP

ESHAP is the name of a cancer drug combination. It includes the drugs we list below, next to each drug we have how you pronounce the drug name in brackets.

E – etoposide (ee-top-o-side)

S – solu-medrone (sol-you-med-rone), you commonly hear it called methylprednisolone

HA – high dose cytarabine (sye-ta-ra-bin), also known as Ara C

P – cisplatin (sis-pla-tin)

It is a treatment for lymphoma and myeloma. It is usually used before having a stem cell transplant using your own stem cells (autologous transplant Open a glossary item).

For some types of non-Hodgkin lymphoma (NHL), you might also have ESHAP with a drug called rituximab. This is called R-ESHAP.

How does ESHAP work?

Etoposide, cisplatin and cytarabine are chemotherapy drugs. These drugs destroy quickly dividing cells, such as cancer cells.

Methylprednisolone is a type of steroid. It treats lymphoma by stopping the cancer cells growing and killing them. It may also help you feel less sick during treatment.

How do you have ESHAP?

You usually have all drugs as a drip into your bloodstream (intravenously). In some hospitals you might take methylprednisolone as a tablet.

Drugs into your bloostream

You might have treatment through a long plastic tube that goes into a large vein in your chest. The tube stays in place throughout the course of treatment. This can be a:

  • central line
  • PICC line
  • portacath

Taking your tablets

You must take tablets according to the instructions your doctor or pharmacist gives you.

You should take the right dose, not more or less.

Talk to your healthcare team before you stop taking a cancer drug, or if you miss a dose.

How often do you have ESHAP?

You usually have ESHAP as cycles of treatment. This means you have the drugs and then a rest to allow your body to recover. Each cycle lasts 3 weeks (21 days).

If you’re having ESHAP before a stem cell transplant you usually have between 2 and 3 cycles of treatment. 

If you’re not having a stem cell transplant you might have up to 6 cycles of treatment.

When having ESHAP in the hospital (an inpatient), you have it slightly different from how you have it in the day care unit (an outpatient).

Below is an example of one way of having ESHAP:

Day 1
  • You start cisplatin as a continuous drip into your bloodstream that lasts for 4 days.
  • You have etoposide as a drip into your bloodstream for 1 hour.
  • You have methylprednisolone as a drip into your bloodstream for 15 to 30 minutes or you take it as a tablet.
Day 2, 3 and 4
  • You continue with the cisplatin drip.
  • You have etoposide as a drip into your bloodstream for 1 hour.
  • You have methylprednisolone as a drip into your bloodstream for 15 to 30 minutes or you take it as a tablet.
Day 5
  • You have methylprednisolone as a drip into your bloodstream for 15 to 30 minutes or you take it as a tablet.
  • Your nurse disconnects the cisplatin drip.
  • You have cytarabine as a drip into your bloodstream over 2 to 3 hours.
Day 6 to 21
  • You have no treatment.

Then you start the next treatment cycle.

You also have G-CSF. This is an injection under the skin (subcutaneous). It helps your body make white blood cells Open a glossary item to lower your chance of getting an infection. You usually start this on day 6 and continue for up to 10 days.

Tests

You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Before treatment starts you have a blood test to check for viruses such as Hepatitis B infection or Cytomegalovirus (CMV) Open a glossary item. This is because infection with these viruses can become active again if you’ve had them in the past. 

What are the side effects of ESHAP?

How often and how severe the side effects are can vary from person to person. They also depend on what other treatments you're having. 

When to contact your team

Your doctor, nurse or pharmacist will go through the possible side effects. They will monitor you during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:

  • you have severe side effects 
  • your side effects aren’t getting any better
  • your side effects are getting worse

Early treatment can help manage side effects better. 

Contact your advice line immediately if you have signs of infection, including a temperature above 37.5C or below 36C.

We haven't listed all the side effects here. Remember it is very unlikely that you will have all of these side effects, but you might have some of them at the same time.

Common side effects

These side effects happen in more than 10 in 100 people (more than 10%). You might have one or more of them. They include:

Increased risk of infection 

Increased risk of getting an infection is due to a drop in white blood cells. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. You might have other symptoms depending on where the infection is.

Infections can sometimes be life threatening. You should contact your advice line urgently if you think you have an infection. 

Acute respiratory distress syndrome (ARDS)

Cytarabine can cause ARDS due to inflammation Open a glossary item of the lungs from infection or injury. It causes a lack of oxygen to your organs such as the lungs, heart and brain. You might have symptoms that include fast and shallow breathing, tiredness, drowsiness, confusion, feeling like you will faint and shortness of breath.

ARDS is life threatening call 999 or get help straight away

Breathlessness 

You might be breathless and look pale due to a drop in red blood cells. This is called anaemia.

Bruising and bleeding 

This is due to a drop in the number of platelets in your blood. These blood cells help the blood to clot when we cut ourselves. You may have nosebleeds or bleeding gums after brushing your teeth. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae).

Rarely you might bleed from other areas of the body. Tell your healthcare team straight away if you notice any bleeding.

Fatigue 

Tiredness and weakness (fatigue) can happen during and after treatment. Doing gentle exercises each day can keep your energy up. Don't push yourself, rest when you start to feel tired and ask others for help.

Feeling or being sick 

Feeling or being sick is usually well controlled with anti sickness medicines. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniques can all help.

It is important to take anti sickness medicines as prescribed even if you don’t feel sick. It is easier to prevent sickness rather than treating it once it has started.

Hair loss

You could lose all your hair. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Your hair will usually grow back once treatment has finished but it is likely to be softer. It may grow back a different colour or be curlier than before. 

Cytarabine syndrome

Cytarabine syndrome sometimes happens about 6 to 12 hours after having this drug. 

It is a combination of symptoms including a high temperature, aching muscles, bone pain, occasionally chest pain, a rash, sore eyes, and extreme weakness. Steroids can help to prevent or treat this syndrome.

Feeling very sleepy

You might feel very tired or find you are falling asleep during the day. Do not drive or operate machinery. Let your doctor know straight away. 

Feeling generally unwell

Speak to your healthcare team if you feel generally unwell after having this treatment.

Inflammation and ulcers of the opening at the end of the bowel (anus)

Talk to the team looking after you about this. They might be able to give you medicines or creams to help with this.

Diarrhoea

Contact your advice line if you have diarrhoea, such as if you've had 4 or more loose watery poos (stools) in 24 hours. Or if you can't drink to replace the lost fluid. Or if it carries on for more than 3 days.

Your doctor may give you anti diarrhoea medicine to take home with you after treatment. Eat less fibre, avoid raw fruits, fruit juice, cereals and vegetables, and drink plenty to replace the fluid lost.

Hearing changes

You might have some hearing loss, especially with high pitched sounds. You might also have some ringing in your ears (tinnitus). Tell your doctor or nurse if you notice any changes.

Eye changes

You might have eye problems including blurred vision, sore, red, itchy, dry eyes or an infection.

Tell your doctor, nurse or pharmacist if you have this. You will have steroid eye drops to help prevent sore eyes.

Difficulty with movement and speech 

You might have problems with your speech. You might be unsteady when you stand and find it difficult to walk. You might have no muscle control causing coordination problems.

Low levels of sodium and magnesium in your body 

You may have changes in levels of minerals and salts in your blood, such as low sodium. Rarely your levels of magnesium can drop. You may not have any symptoms with this drop and they are usually picked up on blood tests.

You have regular blood tests during treatment to check this.

Tummy (abdominal) pain 

Tell your treatment team if you have this. They can check the cause and give you medicine to help. 

Loss of appetite 

You might lose your appetite for various reasons whilst having cancer treatment. Sickness, taste changes or tiredness can put you off food and drinks.

Constipation 

Constipation is easier to sort out if you treat it early. Drink plenty of fluids and eat as much fresh fruit and vegetables as you can. Try to take gentle exercise, such as walking. Tell your doctor, nurse or pharmacist if you are constipated for more than 3 days. They can prescribe a laxative.

Liver changes 

You might have liver changes that are usually mild and unlikely to cause symptoms. These changes are usually picked up on blood tests.

Let your healthcare team know if you are having the following symptoms: yellowing of the skin and white parts of the eyes; feeling or being sick; dark or tea coloured urine; pain in your tummy; rash and feeling tired and weak.

You have regular blood tests to check for any changes in the way your liver is working.

Skin changes 

Skin problems include a skin rash and your skin colour might become darker. Less commonly your skin may peel, get dry, itch or you may develop a break in the skin (ulcer). This usually goes back to normal when your treatment finishes. You’ll get advice on what products you can use on your skin to help.

ESHAP can also cause a severe skin reaction, but this is rare. Symptoms usually start as tender red patches which leads to peeling or blistering of the skin. You might also feel feverish, and your eyes may be more sensitive to light. This is serious and could be life threatening.

Tell your healthcare team if you have any of these symptoms so they can give you medicines to help.

Sore mouth and ulcers

Mouth sores and ulcers can be painful. It helps to keep your mouth and teeth clean, drink plenty of fluids, avoid acidic foods such as lemons. Chewing gum can help to keep the mouth moist. Tell your doctor or nurse if you have ulcers.

A build up fluid in the lungs

A build up of fluid is called oedema. Fluid on the lungs can cause symptoms such as difficulty in breathing especially when you lay down, cough, and you may cough up blood or bloody froth.

Contact your team if you notice any swelling or have changes to your breathing.

Occasional side effects

These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). You might have one or more of them. They include:

  • an allergic reaction that can cause a rash, shortness of breath, redness or swelling of the face and dizziness
  • heart problems including changes to your heart rhythm. Contact your healthcare team straight away if you feel tightness in your chest, pain in your chest, feeling lightheaded, dizzy, pain in different parts of the body, sweating or anxious attack
  • dizziness
  • redness, swelling and pain at the site of injection
  • a second cancer such as leukaemia Open a glossary item 
  • low blood pressure that can cause you to feel lightheaded or dizzy
  • blood clots that can be life threatening; signs are pain, redness and swelling where the clot is. Feeling breathless can be a sign of a blood clot in the lung. Contact your advice line or doctor straight away if you have any of these symptoms
  • a serious condition causing inflammation of the bowel. Symptoms might include diarrhoea, loss of appetite, being sick, swollen tummy or you might notice blood in your poo. Let your team know straight away of you have any of these symptoms

Rare side effects

These side effects happen in fewer than 1 in 100 people (fewer than 1%). You might have one or more of them. They include: 

  • numbness or tingling in fingers and toes can make it difficult to do fiddly things such as doing up buttons
  • changes to your taste
  • seizures (fits)
  • changes in the brain that are usually reversible. This can cause a sudden onset of symptoms. These include headaches, dizziness, confusion, fits (seizures) and changes to your vision

Coping with side effects

We have more information about side effects and tips on how to cope with them.

What else do I need to know

Other medicines, foods and drinks 

Cancer drugs can interact with medicines, herbal products, and some food and drinks. We are unable to list all the possible interactions that may happen. An example is grapefruit or grapefruit juice which can increase the side effects of certain drugs.

Tell your healthcare team about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies. Also let them know about any other medical conditions or allergies you may have.

Loss of fertility 

You may not be able to become pregnant or father a child after treatment with these drugs. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.

Men might be able to store sperm before starting treatment. And women might be able to store eggs or ovarian tissue. But these services are not available in every hospital, so you would need to ask your doctor about this.    

Contraception and pregnancy 

This treatment may harm a baby developing in the womb. It is important not to become pregnant or father a child while you're having treatment and for at least 6 months afterwards.

Talk to your doctor or nurse about effective contraception before starting treatment. Let them know straight away if you or your partner falls pregnant while having treatment.

Breastfeeding 

Don’t breastfeed during this treatment because the drug may come through into your breast milk.

Treatment for other conditions 

Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Immunisations 

Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and one of the shingles vaccines called Zostavax.

You can have:

  • other vaccines, but they might not give you as much protection as usual
  • the flu vaccine (as an injection)
  • the coronavirus (COVID-19) vaccine - talk to your doctor or pharmacist about the best time to have it in relation to your cancer treatment

Members of your household who are aged 5 years or over are also able to have the COVID-19 vaccine. This is to help lower your risk of getting COVID-19 while having cancer treatment and until your immune system Open a glossary item recovers from treatment.

Contact with others who have had immunisations - You can be in contact with other people who have had live vaccines as injections. Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as the oral typhoid vaccine. Sometimes people who have had the live shingles vaccine can get a shingles type rash. If this happens they should keep the area covered.

If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray as this is a live vaccine. This is for 2 weeks following their vaccination.

Babies have the live rotavirus vaccine. The virus is in the baby’s poo for about 2 weeks and could make you ill if your immunity is low. Get someone else to change their nappies during this time if you can. If this isn't possible, wash your hands well after changing their nappy.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

  • Electronic Medicines Compendium 
    Accessed November 2022

  • Immunisation against infectious disease: Chapter 6: General contraindications to vaccination
    Public Health England
    First published: March 2013 and regularly updated on the Gov.UK website

  • COVID-19 - SARS-CoV-2: The Greenbook, Chapter 14a
    Public Health England
    First published: 27 November 2020 and regularly updated on the GOV.UK website

  • COVID-19: guidance for people whose immune system means they are at higher risk
    Department of Health and Social Care, last updated October 2022

  • DT-PACE/ESHAP chemotherapy regimens as salvage therapy for multiple myeloma prior to autologous stem cell transplantation
    L Ainley and others
    British Journal of Haematology, 2021. Volume 192, Issue 3, Pages e73 to e77

Last reviewed: 
13 Jan 2023
Next review due: 
13 Jan 2026

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