Find out what vemurafenib is, how you have it and other important information about taking vemurafenib.
Vemurafenib is a targeted cancer drug (biological therapy) and is also known by its brand name Zelboraf.
It is a treatment for melanoma that has spread to other parts of the body, or that cannot be removed by surgery.
How it works
Vemurafenib is a type of targeted cancer drug called a cancer growth blocker. It stops cells producing a protein called BRAF, which makes some cancer cells grow and divide.
About half (about 50%) of all melanomas make too much BRAF proteins. This is due to a change in the BRAF gene. Vemurafenib is used in people with melanoma whose cancer cells have a change in the BRAF gene.
You usually have a test to check for the gene change before starting treatment with vemurafenib.
How you have it
Vemurafenib comes as tablets. You take it twice a day, 12 hours apart.
The usual dose is 4 tablets in the morning and 4 tablets in the evening. You swallow the tablets whole with a glass of water. It is best to take them with food, or shortly after eating.
Taking your tablets
Speak to your pharmacist if you have problems swallowing the tablets.
Whether you have a full or an empty stomach can affect how much of a drug gets into your bloodstream.
You should take the right dose, no more or less.
Never stop taking a cancer drug without talking to your specialist first.
If you take more vemurafenib than you should
Talk to your doctor immediately.
If you forget to take vemurafenib
Take it straight away if less than 4 hours have passed.
Do not take the tablets if it has been more than 4 hours. Take your next tablets at the usual time. Don't take a double dose to make up for the missed one.
When you have it
You usually carry on taking vemurafenib for as long as it works unless the side effects get too bad.
Tests during treatment
You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
Other medicines, foods and drink
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
Pregnancy and contraception
This drug may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug and for at least 6 months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.
We don’t know how this treatment might affect fertility. You may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
Some men might be able to store sperm before starting treatment. Some women might be able to store eggs or embryos before treatment.
Don’t breastfeed during this treatment because the drug may come through in your breast milk.
Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.
In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and shingles vaccine (Zostavax).
- have other vaccines, but they might not give you as much protection as usual
- have the flu vaccine
- be in contact with other people who've had live vaccines as injections
Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, avoid changing their nappies for 2 weeks after their vaccination if possible. Or wear disposable gloves and wash your hands well afterwards.
You also need to avoid anyone who has had oral polio or typhoid vaccination recently.
More information about this treatment
For further information about this treatment go to the electronic Medicines Compendium (eMC) website.
You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.