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In situ breast carcinoma incidence statistics

Incidence statistics for in situ breast carcinoma by country in the UK, age and trends over time are presented here. The ICD code for in situ breast carcinoma is ICD-10 D05. There are two main types of in situ breast carcinoma: lobular carcinoma in situ (LCIS; ICD-10 D05.0) and ductal carcinoma in situ (DCIS; ICD-10 D05.1).

In situ breast carcinoma is a non-invasive tumour of the breast, which is different to invasive breast cancer. In situ breast carcinoma carries a raised risk for developing invasive breast cancer, and is sometimes considered pre-invasive disease or “early breast cancer”.1 There are many other benign breast conditions, but these are not reported here.

Due to the small number of men diagnosed each year most of the information on this page refers to females only.

The latest incidence statistics available for in situ breast carcinoma in the UK are 2010.  Find out why these are the latest statistics available.

 

By country in the UK

In 2010, there were 5,791 new cases of in situ breast carcinoma in the UK (Table 1.1): 5,765 (99.6%) in women and 26 (0.4%) in men, giving a female:male ratio of around 222:1.2-5 The crude incidence rate shows that there are 18 new in situ breast carcinoma cancer cases for every 100,000 females in the UK, and 0.1 for every 100,000 males.

The European age-standardised incidence rate (AS rate) of in situ breast carcinoma in females is significantly lower in Scotland than in England (Table 1.1).2-5 There are no other significant differences between the constituent countries of the UK.

Table 1.1: In Situ Breast Carcinoma (D05), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2010

England Wales Scotland Northern Ireland UK
Male Cases 20 1 3 3 27
Crude Rate 0.1 0.1 0.1 0.3 0.1
AS Rate 0.1 0.0 0.1 0.3 0.1
AS Rate - 95% LCL 0.0 -0.0 -0.0 -0.0 0.0
AS Rate - 95% UCL 0.1 0.1 0.1 0.7 0.1
Female Cases 4,917 286 527 163 5,893
Crude Rate 18.2 18.3 19.5 17.6 18.3
AS Rate 16.5 15.8 16.3 16.7 16.5
AS Rate - 95% LCL 16.0 14.0 14.9 14.2 16.0
AS Rate - 95% UCL 17.0 17.6 17.7 19.3 16.9

Download this table XLS (33KB) PPT (148KB)

95% LCL and 95% UCL are the 95% lower and upper confidence limits around the AS Rate

section reviewed 07/11/12
section updated 07/11/12

 

By age (females)

In situ breast carcinoma incidence is related to age, with the highest incidence rates being in women in their 50s and 60s. In the UK between 2008 and 2010, an average of 69% of cases were diagnosed in women aged between 50-54 and 65-69 (Figure 1.1).2-5 Screening is a major driver behind the pattern of in situ breast carcinoma diagnoses.6,7 In the UK women aged 50-70 are invited for screening every three years, and women aged over 70 can request an appointment.8 In England a trial is taking place to look at the possible benefits of extending breast screening so that women aged 47 to 50 and 70 to 73 are also invited.

The remainder of cases are split evenly between women either side of the screening age group, with 16% of cases diagnosed in women aged 49 and younger, and 16% in women aged 70 and older. Age-specific incidence rates rise steeply from around age 30-34, peak at age 50-54, drop slightly at age 55-59 before a second peak at 65-69, then decrease steeply until 75-79 and more steadily thereafter.2-5

A recent study of in situ breast carcinoma in England during 2006-2007 showed that more than 60% of cases are screen-detected; the remainder of cases are diagnosed outside of the screening programme (possibly as a result of routine diagnostic radiology for other medical purposes).7

Figure 1.1: In Situ Breast Carcinoma (D05), Average Number of New Cases per Year and Age-Specific Incidence Rates, Females, UK, 2008-2010

cases_crude_f_is_breast.swf

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section reviewed 07/11/12
section updated 07/11/12

 

Trends over time (females)

In situ breast carcinoma incidence rates have overall increased more than five-fold in Great Britain since the late 1970s (Figure 1.2).2-4 The largest increases have been observed since the national screening programmes were introduced in the UK in the late 1980s. In the first decade of screening, European AS incidence rates increased by almost two-and-a-half times (142% increase between 1988-1990 and 1997-1999) as a prevalent pool of undiagnosed carcinomas were detected in the population. Since then, rates have increased by more than half again (62% increase between 1997-1999 and 2008-2010) (Figure 1.2).2-4

Figure 1.2: In Situ Breast Carcinoma (D05), European Age-Standardised Incidence Rates, Females, Great Britain, 1979 -2010

inc_asr_gb_f_is_breast.swf

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In situ breast carcinoma incidence trends for the UK are shown in Figure 1.3.2-5 Over the last decade (between 1999-2001 and 2008-2010), the European AS incidence rate has increased by 44%.

Figure 1.3: In Situ Breast Carcinoma (D05), European Age-Standardised Incidence Rates, Females, UK, 1993-2010

inc_asr_uk_is_breast.swf

Download this chart XLS (45KB) PPT (126KB) PDF (37KB)

In situ breast carcinoma incidence rates have overall increased for all broad age groups in Great Britain since the late 1970s (Figure 1.4).2-4 The largest increases have been in women of screening age, with European AS incidence rates increasing more than nine-fold in women aged 50-64, and more than 11-fold in those aged 65-69, between 1979-1981 and 2008-2010. These increases were steepest in the late 1980s and early 1990s for women aged 50-64, and in the early 2000s for women aged 65-69; this corresponds with the start of the screening programmes for 50-64 year olds in the late 1980s, and then the extension to include women aged 65-69 from 2001 onwards (Figure 1.4).2-4 Improvements in screening methods (such as the introduction of two-view mammography), better population coverage and improved screening uptake rates will also have contributed to increases in incidence rates for these age groups.6 The option for women aged over 70 to request screening appointments will partly explain the increasing incidence rates in this age group.6

Figure 1.4: In Situ Breast Carcinoma (D05), European Age-Standardised Incidence Rates, Females, by Age, Great Britain, 1979-2010

inc_asr_age_f_is_breast.swf

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section reviewed 07/11/12
section updated 07/11/12

 

Distribution of cases (females)

The majority of in situ breast carcinomas are ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). In Great Britain between 2008 and 2010, an average 83% of cases were DCIS, and 9% were LCIS. The remaining 7% of cases were registered as either ‘other’ or ‘unspecified’ (Table 1.2).2-4

Table 1.2: In Situ Breast Carcinoma (D05), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, Females, Great Britain, 2008-2010

Sex D050: Lobular Carcinoma In Situ D051: Ductal Carcinoma In Situ D057: Other Carcinoma In Situ of Breast D059: Carcinoma In Situ of Breast, Unspecified
Female Cases 525 4,647 301 103
Crude Rate 1.7 15.2 1.0 0.3
AS Rate 1.6 13.7 0.9 0.3
AS Rate - 95% LCL* 1.5 13.4 0.8 0.3
AS Rate - 95% UCL* 1.7 13.9 0.9 0.3

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*95% LCL and 95% UCL are the 95% lower and upper confidence limits around the AS Rate

Incidence of DCIS peaks at a slightly later age than that of LCIS. The highest rates in Great Britain in 2008-2010 were in the 65-69 age group for DCIS, and in the 50-54 age group for LCIS. The over-65s represent 32% of DCIS cases and 22% of LCIS cases (Figure 1.5).2-4

Figure 1.5: Lobular Carcinoma In Situ (D05.0) and Ductal Carcinoma In Situ (D05.1), Average Number of New Cases per Year and Age-Specific Incidence Rates, Females, Great Britain, 2008-2010

cases_crude_f_is_breast1.swf

Download this chart XLS (55KB) PPT (126KB) PDF (37KB)

section reviewed 07/11/12
section updated 07/11/12

 

By socio-economic group (females)

A quarter of women diagnosed with in situ breast carcinoma in England during 2006-2007 live in the least deprived areas of England, while only 13% live in the most deprived areas.7 A similar distribution of cases by deprivation is also reported for invasive breast cancer.7

section reviewed 07/11/12
section updated 07/11/12

 

By ethnicity (females)

The vast majority (94%) of women diagnosed with in situ breast carcinoma in England during 2006-2007 are white (according to hospital admission records; 28% of women were excluded from the study because their ethnicity could not be determined).7 A similar ethnic profile is also reported for invasive breast cancer.7

section reviewed 07/11/12
section updated 07/11/12

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References for in situ breast carcinoma incidence

  1. Robinson D, Holmberg L, Moller H. The occurrence of invasive cancers following a diagnosis of breast carcinoma in situ. Br J Cancer 2008.99(4):611-15.
  2. Data were provided by the Office for National Statistics on request, June 2012. Similar data can be found here: http://www.ons.gov.uk/ons/search/index.html?newquery=cancer+registrations  
  3. Data were provided by ISD Scotland on request, April 2012. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp#605  
  4. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, April 2012. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=51358  
  5. Data were provided by the Northern Ireland Cancer Registry on request, June 2012. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/CancerData/OnlineStatistics/
  6. Glover JA, Bannon FJ, Hughes CM, et al. Increased diagnosis and detection rates of carcinoma in situ of the breast. Breast Cancer Res Treat. 2012;133(2):779-84.
  7. West Midlands Cancer Intelligence Unit. The Non-Invasive Breast Cancer report: An analysis of non-invasive breast cancers diagnosed in England from 1 January 2006 to 31 December 2007 (PDF 342KB). National Cancer Intelligence Unit, 2011.
  8. UK National Screening Committee. UK Screening Portal: Breast screening across the UK. Accessed October 2012.
Updated: 7 November 2012