“I had treatment last year and I want to give something back.”
A trial looking at stopping tamoxifen after 5 years or continuing treatment to 10 years in women with early breast cancer (aTTom)
This analysis compared 5 years and 10 years of tamoxifen treatment for breast cancer. The trial was supported by Cancer Research UK.
But researchers wanted to find out if taking tamoxifen for longer was better than taking it for the recommended 5 years.
The women taking part in this trial had breast cancer that was either oestrogen receptor positive, or the oestrogen receptor status wasn’t known.
The aim of the trial was to find out if taking tamoxifen for longer than 5 years would
- Reduce the risk of breast cancer recurrence even more
- Increase side effects
Summary of results
The trial team found that taking tamoxifen for 10 years rather than 5 reduced the risk of breast cancer coming back.
This analysis included 6,953 women who had been taking tamoxifen for over 4 years. Half the women stopped taking tamoxifen after 5 years and half carried on taking it.
In 2013, the researchers presented their findings at a large cancer conference. They looked at the number of women who’d had a recurrence of breast cancer and found it was
- 580 out of 3,468 women who had continued to take tamoxifen
- 672 out of 3,485 who had stopped taking it after 5 years
They also looked at the number of women who had died and found it was
- 910 in the group of women who took tamoxifen for 5 years
- 849 in the group who carried on taking it for longer
One side effect of tamoxifen is an increase in the risk of womb cancer. The number of women who had developed womb cancer was
- 102 in the group of women who continued to take tamoxifen
- 45 in the group who had stopped taking it
But womb cancer can be treated successfully if caught early and the number of deaths from womb cancer was 37 if tamoxifen was taken for 10 years and 20 if taken for just 5 years
The trial team concluded that taking tamoxifen for longer than 5 years reduces the risk of breast cancer coming back and that the benefits outweigh the risks.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Daniel Rea
Professor Richard Gray
Cancer Research UK
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer
University of Birmingham
This is Cancer Research UK trial number CRUK/94/001.