"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A trial of exercise as treatment for men with prostate cancer (PANTERA)
This trial is looking at exercise as a treatment for men with prostate cancer. The trial is for men with prostate cancer that is completely contained in the prostate gland (localised prostate cancer). This trial is supported by Cancer Research UK.
We know from research that exercise can improve your fitness, strength, overall health and quality of life. It may also slow down the growth of cancer.
More about this trial
This is a feasibility study. The researchers want to find out if it is possible to do a trial comparing men who have prostate cancer and follow an exercise programme with men who don’t. They want to find out
- How willing men are to take part in a trial looking at exercise
- If the men will attend all the necessary exercise sessions and assessments
- If there may be any undesirable effects of the exercise programme
Who can enter
You may be able to join this trial if all of the following apply. You
- Have prostate cancer and you have had a PSA blood test and a
scanor sample of tissue taken ( biopsy) to assess your cancer in the past year
- Have a
Gleason scoreof 7 or less (the trial team will advise you about this)
- Have cancer that is completely contained within the prostate gland
- Have a PSA blood test result of 20 ng/ml or less
- Are willing to have your cancer closely monitored (active surveillance)
You cannot join this trial if any of these apply. You
- Have already had surgery, radiotherapy or hormone treatment for your prostate cancer
- Have prostate cancer that is in more than one half of the prostate gland (your doctor can tell you this)
- Have certain heart problems (the trial team can advise you about this)
- Have a pacemaker
- Already do a certain amount of regular exercise (the trial team can advise you about this)
- Are taking part in another clinical trial that may affect the results of this study
- Have another medical or mental health problem that could affect you taking part in this trial
This is a feasibility study. The researchers need 50 men to join.
It is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.
- Men in one group have an individual exercise plan created for them
- Men in the other group will be given a physical activity pack
All the men taking part will have their cancer closely monitored (active surveillance) by their doctor.
Men who have an exercise plan created for them will go to a training session twice a week for a year. This can be during a week day or evening. You will also need to follow an exercise plan at home in your own time. Every 2 months they will also give you advice and support about how to change your behaviour. This may be done at your exercise sessions or over the phone.
The physical activity pack given to the other men will tell them generally about exercise for people living with and beyond cancer.
The researchers will collect a sample of your spit (saliva), by asking you to spit into a small test tube. They will use this to look at the
The trial team will ask you to fill out a questionnaire before you start treatment, at 3 months, 6 months and at the end of the study. The questionnaire will ask about your exercise and diet habits as well as how you are generally.
At the end of the trial, the researchers want to interview about 10 to 15 men. They want to find out why they took part and their overall experience of taking part in the trial. You don’t have to agree to this if you don’t want to. You can still take part in the main trial.
You see the doctor to have some tests before taking part. These tests include
- A physical examination
- Blood tests
- Test of your fitness using a treadmill or exercise bike
You see the doctor again at 3 months, 6 months and a year for the same tests.
If you are going to the interview at the end of the trial, it will take place at Sheffield Hallam University.
The trial team don’t expect there to be any side effects from taking part.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Liam Bourke
Cancer Research UK
Sheffield Teaching Hospitals NHS Foundation Trust
This is Cancer Research UK trial number CRUK/13/071.