A trial looking at treatment for fluid around the lung caused by mesothelioma (MesoVATS)

Cancer type:

Mesothelioma

Status:

Results

Phase:

Phase 3

This trial looked at 2 procedures for people with pleural mesothelioma to see which works best to prevent a buildup of fluid around the lung.

Pleural mesothelioma is cancer of the lining of the lungs (pleura). It can cause fluid to collect between the lining of the lung and the lining of the chest wall. This is called a pleural effusion . It causes shortness of breath because the fluid gets in the way and the lungs cannot expand fully.

More about this trial

Doctors can drain off the fluid to help relieve shortness of breath. But it usually builds up again over time. Sticking the lining of the lung to the chest wall can stop this happening. The 2 main ways to do this are

  • Putting talc through a tube into the space between the lungs and the chest wall (talc pleurodesis)
  • An operation to remove the membrane around the lungs (pleurectomy)

The doctors in this trial removed part of the membrane around the lung. This is called a video assisted thorascopic partial pleurectomy or a VAT-PP. They compared a pleurodesis with a VAT-PP to find out more about

  • How long people lived for after the procedure
  • The side effects and cost
  • Quality of life after the procedure

Summary of results

The trial team found that VAT-PP improved quality of life for up to a year, but it did not improve overall survival in this group of people.

196 people took part in the trial and

  • Half had talc pleurodesis
  • Half had video assisted thorascopic partial pleurectomy (VAT-PP)

The researchers looked at the average length of time people lived after joining the trial. Doctors call this overall survival. They found no difference between the 2 groups.

The researchers also looked at how much the procedures cost. They found that on average VAT-PP cost £3,800 more than talc pleurodesis. This was because the actual procedure cost more, it resulted in longer hospital stays and more people had to come back into hospital because of side effects. These included breathing problems and other surgical complications.

When the researchers looked at quality of life Open a glossary item they found that the people who had VAT-PP rated their quality of life higher than those who had talc pleurodesis at 6 months and 12 months after the procedure.

The trial team concluded that VAT-PP improved quality of life for up to a year, but it did not improve overall survival in this group of people. Talc pleurodesis cost less, had fewer side effects and shorter hospital stays.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Robert Rintoul

Supported by

BUPA Foundation
National Institute for Health Research Cancer Research Network (NCRN)

Contact our cancer information nurses for other questions about cancer by:

Phone - 0808 800 4040

Last review date

CRUK internal database number:

Oracle 394

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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