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A trial comparing chemotherapy before and after surgery with chemoradiation before surgery for cancer of the food pipe (Neo-AEGIS)

Overview

Cancer types:

Oesophageal cancer

Status:

Results

Phase:

Phase 3

Details

This trial compared 2 standard treatments for cancer of the food pipe (oesophagus). The 2 treatments were:

  • chemotherapy before and after surgery

  • chemotherapy and radiotherapy together (chemoradiotherapy) before surgery

It was for people with cancer of the:

  • oesophagus (food pipe)

  • area where oesophagus joins the stomach (gastro oesophageal junction)

In the UK, this trial was supported by Cancer Research UK. It was open for people to join between 2013 and 2020. The team published the results in 2023.

Recruitment start: 24 January 2013

Recruitment end: 23 December 2020

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Shaun Preston

Supported by

Cancer Research UK

Cancer Trials Ireland

Experimental Cancer Medicine Centre (ECMC)

French National Cancer Institute

Health Research Board Ireland

Irish Cancer Society, Oesophageal Cancer Fund

NIHR Clinical Research Network: Cancer

Southampton Clinical Trials Unit

Other information

This is Cancer Research UK trial number CRUK/14/017.

Last reviewed: 11 May 2025

CRUK internal database number: 12058

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