"I am glad that taking part in a trial might help others on their own cancer journey.”
A study looking at improving radiotherapy for bladder cancer - APPLY
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at using a new type of CT scanning to improve radiotherapy treatment for people with invasive bladder cancer. This new type of CT scanning is called a ‘Cone beam’ CT scan and is taken when you have your radiotherapy treatment.
Doctors often treat invasive bladder cancer with radiotherapy. Before starting treatment the doctors will carefully plan your radiotherapy treatment, so they know how much to give and where to give it. This is to make sure that they give the highest dose of radiation to your cancer and as little as possible to the surrounding healthy tissue. As a part of the planning they will do a ‘planning CT scan’.
The doctors will ask you to empty your bladder before the planning CT scan and your treatment to make sure that the bladder is in the same position. But the bladder is a stretchy bag of muscle that can change size, shape and position.
We know from research that even if the bladder is empty this does not mean that it will be the same size, shape or in the same position for treatment as it was for the planning CT scan.
In this study the researchers will make a set of treatment plans so that they are able to treat the different sizes of the bladder.
The researchers want to use the ‘Cone beam’ CT scan pictures taken before each treatment to make sure that they can choose the best treatment on that day.
The aim of this study is to see if using the ‘Cone beam’ CT scanning can improve the radiotherapy treatment given to people with invasive bladder cancer.
Who can enter
You can enter this trial if you
- Have cancer of the bladder that has spread into the muscle layer or if it has spread outside the bladder it has not gone beyond the
prostate, womb ( uterus) or vagina(stage T2 to T4a)
- Are due to have radiotherapy once a week to treat your bladder cancer (your doctor can advise about this)
- Are at least 18 years old
You cannot enter this trial if you
- Have had radiotherapy to the area between your hips before (your pelvis)
- Have a tube into your bladder to drain your urine (urinary catheter)
This is a phase 2 study. It will recruit about 42 people from the Royal Marsden NHS Foundation Trust.
You will have 1 treatment (fraction) of radiotherapy to your bladder each week, for 4 to 6 weeks. Before and after each treatment, the study team will use a special CT scanner to scan your bladder. They will do this in the treatment room where you have your radiotherapy.
They will use the results of the scan before treatment, to plan exactly where to treat your bladder on that day.
They will take another scan after your treatment to confirm they have treated that area.
Taking the scan before and after each radiotherapy session will only add about 4 minutes to the total time of each session.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Robert Huddart
Institute of Cancer Research (ICR)