A study collecting samples to help doctors learn more about cancer and other illnesses

Cancer type:

Bladder cancer
Bowel (colorectal) cancer
Brain (and spinal cord) tumours
Kidney cancer
Ovarian cancer
Prostate cancer





This study is looking at tissue, blood, urine and a type of fluid that can build up in your body called ascitic fluid to understand how the human body works normally, and what changes when things go wrong.

In Leeds, many people are carrying out research into a range of illnesses, including cancer. Each team has different reasons for their research, but they are mainly to try and understand more about what has changed in these diseases and why.

Changes in proteins, genes or other substances the researchers find may be markers for the particular disease they are investigating (biomarkers). They may be able to use these to develop new biomarker tests. These tests could help diagnose a disease earlier, or monitor how a patient is responding to treatment. Studying samples may also help researchers understand why the disease has developed. So they may then be able to find ways of preventing it. Or, they could use the samples to develop better treatments for diseases.

Samples from healthy volunteers and people with minor or major illnesses are important to researchers, as they need to compare them and see what is normal and what changes in different diseases. In this study, the team will ask permission to collect spare tissue from surgery, and also blood, urine and ascitic fluid from people already giving these as part of routine treatment. Healthy volunteers will also be able to give blood samples. Samples will be stored in the ‘Leeds Multidisciplinary Research Tissue Bank’.

Who can enter

Researchers in Leeds hope in future to get permission for a wider group of people to give samples. At the moment, you can take part in this study if you are in Leeds and are in one of the following situations

  • You have kidney cancerprostate cancer, bladder cancer, bowel cancer or a brain tumour
  • You have ovarian cancer, or are having surgery to remove your ovaries (a bilateral oophorectomy) to reduce your risk of ovarian cancer
  • You have any other kidney or urinary tract disease that is not cancer, for example repeated urine infections, kidney stones or kidney failure
  • You do not have cancer, but are due to have surgery for another condition
  • You do not have any health problems, but would like to take part in the study (you are a healthy volunteer)

You cannot enter this study if

  • For any reason you are not able to understand what the study involves and give permission (consent) for samples to be used
  • You are being cared for in prison
  • You have an infectious disease such as HIV, Hepatitis B or Hepatitis C, or are thought to be at high risk for these diseases
  • You are under 18 years of age

Trial design

Everyone taking part in the study will give one or more samples, depending on their situation. You will also give permission for the team to look at information from your medical records that would help them in this research. They will treat this information anonymously, so no one can link it to you.

If you are having surgery, the team will ask permission to store and study any tissue removed during your surgery that your medical team do not need to keep.

The team will also ask if you would be willing to give one or more blood samples. How many you give depends on your situation, and the team will tell you more about this. You may also be asked to give a urine sample.

The team may ask if you would be willing to give further samples during future hospital visits. They will explain how they will use any samples you give.

Samples may be used in studies looking at genetic material. The samples may undergo a process called ‘whole genome sequencing’, which could determine many or all of the features of your DNA, if you agree to this.

Hospital visits

Where possible, you will give samples when you are already at the hospital. If you are a healthy volunteer and not due to have any blood tests, you will need to make an extra hospital visit to take part.

Side effects

You should not have any side effects from taking part in this study.

It is possible that some of the information the team discover may show changes that could be relevant to other illnesses. For example, they may find that you are at risk of an illness determined by the genes you carry, which may also affect others in your family, or they may provide information which may be relevant to your treatment. As the tests the team carry out are only for research, any results like this would need to be checked by a doctor. You can choose whether you would like the team to keep any information of this kind confidential, or if you would like them to contact your doctor who could look into any possible illness with you.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Rosamonde Banks

Supported by

Brain Tumour Research and Support across Yorkshire (BTRS)
Cancer Research UK
Department of Health
European Union
The PPR Foundation

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

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