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General radiotherapy side effects

Radiotherapy effects on your blood

Radiotherapy can affect your bone marrow and blood cells. This is more likely if you're having treatment to a large area of your body. 

How radiotherapy affects your blood

Radiotherapy sometimes slows down the cells in the  that make your blood cells. 

This is more likely if you're having treatment to a large area of your body. Or having treatment to your:

  • leg bones

  • chest

  • tummy (abdomen)

  • pelvis

Having chemotherapy with radiotherapy can make the effects on the bone marrow worse. You have blood tests before your chemotherapy to check your blood count. 

Find out what chemotherapy is

Effects of low blood cell levels

Tiredness and feeling short of breath

You can feel tired and breathless if your level of red blood cells is low. This is called anaemia. You might need a blood transfusion to boost your red blood cell count. Or your doctor may suggest that you have hormone injections (erythropoietin injections). The injections encourage the body to make red blood cells.

Higher risk of infection

You could be more at risk of getting infections if your white blood cell count falls very low. This is called neutropenia. You might need a short rest from treatment so that your blood count can go back to normal.

Chemotherapy can also affect the number of white blood cells. So having chemotherapy and radiotherapy together can make this worse.

Total body irradiation (TBI)

You have total body irradiation (TBI) before a stem cell or bone marrow transplant.

TBI can affect your red and white blood cells. It can also affect your platelet count. Platelets clot the blood and if they are low you might be at risk of bruising and bleeding. 

Because of this, you have regular blood tests during your treatment to check that you have enough red and white blood cells and platelets. 

Find out more about total body irradiation (TBI)

Worries about treatment side effects

You may feel anxious about radiotherapy side effects and this is normal. It can help to talk through any worries you have with your doctor, nurse or radiographer.

Coping with cancer

Last reviewed: 18 Mar 2024

Next review due: 18 Nov 2027

General side effects of radiotherapy

Radiotherapy can cause some general side effects, such as tiredness and skin reactions.

Radiotherapy to relieve symptoms

Radiotherapy for symptoms or palliative treatment aims to shrink a cancer, slow down its growth and control symptoms.

What is radiotherapy?

Radiotherapy is a treatment for cancer. It can be used to try to cure cancer, reduce the chance of cancer coming back or to help relieve symptoms.

Your blood, bone marrow and cancer drugs

Cancer drugs can cause bruising and bleeding, an increased risk of infection and breathlessness. But there are treatments that can help.

Other treatments

Treatments can include surgery, radiotherapy and drug treatments (such as chemotherapy, hormone therapy or targeted cancer drugs). Find out about treatments and how to cope with side effects.

Radiotherapy main page

Find out about cancer treatment with radiotherapy, including external radiotherapy, internal radiotherapy, side effects, radiotherapy for symptoms and follow up after treatment.

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