Chemotherapy cream for skin cancer

Chemotherapy is a type of anti cancer drug treatment. It uses anti cancer (cytotoxic) drugs to destroy cancer cells.

Different chemotherapy drugs work in different ways. They mainly kill cancer cells by disrupting the way they work. To treat skin cancers, you might have chemotherapy as a cream (topical treatment) directly on to your skin cancer.

It is very rare for doctors to use chemotherapy through a drip into a vein, to treat skin cancer.

Chemotherapy cream (topical)

The chemotherapy drug fluorouracil (5FU) comes in a cream called Efudix. You spread the cream on your skin. This is called topical chemotherapy. It treats the cancer cells where you apply it. Very little of the drug is absorbed into the rest of your body. 

It is only used for cancers affecting the top layer of skin (superficial skin cancers). So you might have it to treat:

  • some thin basal cell skin cancers (BCCs)
  • Bowen's disease (squamous cell carcinoma in situ)
  • actinic keratosis, which might develop into a squamous cell skin cancer

You put the chemotherapy cream on your skin cancer yourself. Hospital staff will show you how to do this so you can do it at home.

Usually you apply the cream once or twice a day for 3 to 4 weeks. Depending on where the skin cancer is, you might have waterproof dressings to put over the cream to keep it in place. 

The cream can make the skin red, sore and inflamed. Some people's skin reacts more than others. To relieve discomfort, your doctor or specialist nurse can give you another cream containing steroids, if needed. 

Your skin should heal completely after one to two months. Contact your advice line if you’re worried about the side effects you are experiencing.

Related links