Leptomeningeal metastases
Doctors are still looking at which treatments best enter the cerebrospinal fluid (CSF). They also want to know how well they work at treating leptomeningeal metastases and their side effects.
The CSF is a clear fluid that surrounds the brain and spinal cord. The CSF supports and protects the brain and the spinal cord.
Below is an overview of some of the treatments you might have depending on where the cancer started (primary cancer):
Researchers continue to look into the best treatment for cancers that have spread. This includes leptomeningeal metastases. Research is looking at:
combinations of drugs
newer targeted cancer drugs
drugs that help the immune system to fight cancer cells (immunotherapy)
It can be difficult to cope with leptomeningeal metastases. Your doctor and cancer nurse specialist are your best source of information. You can ask them if there are any cancer support groups in your area or any local groups that offer practical help. It might help to speak to other people in a similar situation to you.
You can also call the Cancer Research UK information nurses on freephone 0808 800 4040. The lines are open from 9am to 5pm, Monday to Friday.
If you want to find people to share experiences with online, you could use Cancer Chat, our online forum.
It can help to talk to those close to you. Some people decide that they would like to try counselling.
Last reviewed: 30 Aug 2023
Next review due: 30 Aug 2026
Leptomeningeal metastases mean cancer cells have spread to the thin tissue layers covering the brain and spinal cord (the leptomeninges).
Coping with secondary cancer can be very difficult. Getting the help and support you and your family need can help.
Treatments can include surgery, radiotherapy and drug treatments (such as chemotherapy, hormone therapy or targeted cancer drugs). Find out about treatments and how to cope with side effects.
Coping with cancer can be difficult. There is help and support available. Find out about the emotional, physical and practical effects of cancer and how to manage them.
Leptomeningeal metastases mean cancer cells have spread to one of the membranes that surround the brain.
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