Side effects of stem cell or bone marrow transplant

The possible side effects of a transplant depend on your:

  • treatment schedule 
  • type of transplant 

High dose chemotherapy can have the same side effects as standard chemotherapy. You have the same chemotherapy drugs. But as you are having higher doses, the side effects might be more severe.

You might have additional side effects if you also have radiotherapy to your whole body (total body irradiation).

Side effects of high dose chemotherapy

Chemotherapy side effects can start straight after your treatment and last for some time afterwards. When your blood counts start to rise you usually start to feel better. 

Let your team know about any side effects. They can help to relieve some of these. 

You have fewer white blood cells in your bloodstream after your treatment. This means you are more at risk of getting an infection. You are most likely to get an infection from the normally harmless bacteria we all have in our digestive systems and on our skin.

To help prevent infection from body bacteria, you might have mouthwashes and tablets known as gut sterilisers (these are antibiotics). And your nurse will encourage you to have a shower each day.

You are also at risk of infection from food. The nurses on the ward will tell you and your relatives about the food you can and can't eat. Advice might include:

  • hot meals must be thoroughly cooked and eaten fresh
  • fruit must be washed and peeled
  • salads must be carefully washed (but are usually not allowed)
  • you can't have lightly cooked or raw eggs
  • you can't have fresh cream or soft cheese

You are at risk of getting an infection called cytomegalovirus (CMV) Open a glossary item which can affect the lungs. Let your doctor or nurse know if you feel breathless.

The domestic staff clean your room every day. Your visitors have to wash their hands before they come into your room. And they might have to wear disposable gloves and aprons. Visitors with coughs and colds are not allowed. Some hospitals don't allow you to have flowers in your room, because germs can grow in the water.

Even with all these precautions, most people do get an infection at some point and have to have antibiotics. You can help yourself by trying to take care of your mouth properly, getting up to shower and having your bed changed each day. It is important to try to do this even on the days when you really don't feel like it.

Your red blood cell count falls after your treatment. If it falls too low, you feel very tired and have little or no energy. You might also feel breathless when you move around. This is because red blood cells contain haemoglobin which carries oxygen around the body. Your doctor will check your blood counts each day. 

You can have a blood transfusion if you are anaemic. This can help you to feel better very quickly.

Some people have a reaction to the blood, although this is rare. Tell your doctor or nurse if you feel hot or cold and shivery during the infusion. Your nurse will give you medicines to reduce the reaction.

Your platelet levels in the blood will fall after your treatment. Platelets help the blood to clot. A low platelet level means you are at risk of bleeding. Tell your nurse or doctor straight away if you have any of the following signs:

  • blood in your urine
  • blood when you have your bowels open
  • bruises or tiny red spots on your skin
  • nosebleeds
  • bleeding gums

You might need a platelet transfusion. 

Some people have a reaction to the platelets. This can make you feel hot, itchy and shivery when you are having the transfusion. Tell your doctor or nurse if you have this. They will give you medicines to reduce the reaction.

Your platelet count can take quite a while to get back to normal after a bone marrow or stem cell transplant. After having your own stem cells (an autologous transplant) it can take a few months to really recover. 

Once you finish your chemotherapy and radiotherapy, any sickness problems you have had should start to get better. Some of the other treatments you have might also make you feel sick, such as antibiotics. You can have anti sickness drugs for this.

Diarrhoea can develop as a reaction to the radiotherapy or to some chemotherapy drugs. You can have tablets to control diarrhoea if you need them.

Mouth ulcers are very common after a transplant. They can develop as a reaction to chemotherapy or radiotherapy or from a mouth infection.

Your nurse can give you mouthwashes and sometimes lozenges or pastilles to suck to try to prevent infection. You must be very careful not to damage the lining of your mouth. It can be very delicate just after a transplant. If your mouth is very sore, tell your nurse. They can give you painkillers.

You might not have much appetite just after your transplant if you are coping with sickness, diarrhoea and a sore mouth. You could try small meals, snacks and drinks throughout the day. Your dietitian can give you high calorie and high protein drinks if you can't eat much.

You might have liquid food through your central line if you find it difficult to eat anything for a while, or if you have lost a lot of weight. This is called total parenteral nutrition (TPN). It gradually stops as you get better and begin to eat more.

You can expect to feel very tired and run down after your transplant. The tiredness is usually at its worst during the second and third weeks, when your blood counts are at their lowest.

When your blood counts start to pick up, you start to feel better. You have less risk of getting infections. And you don't need blood and platelet transfusions so often. As side effects wear off, your appetite usually begins to come back.

Slowly you start to feel that you have more energy. But you do feel more tired than usual for quite a long time after your transplant. You might tire more easily than usual for several months.

Side effects of radiotherapy

Treatment for non-Hodgkin lymphoma can include whole body radiotherapy. This is called total body irradiation (TBI). It happens after high dose chemotherapy, just before you have your stem cell or bone marrow transplant. 

Radiotherapy side effects include:

  • feeling or being sick
  • tiredness and weakness (fatigue)
  • diarrhoea 

You might sleep a lot for a few days after the treatment. Your nurses make sure you have as much anti sickness medicine as you need. Do tell your nurses about sickness and diarrhoea so they can give you something to help control it.


Infertility is a long term side effect of this type of treatment. This is due to the high doses of chemotherapy. Most people can no longer have children. This can be very difficult for some people to cope with.

Sometimes men and teenage boys can store sperm before they start their chemotherapy, so that they can still father a child in the future. This is called sperm banking. Ask your doctor if you think you would like to do this.

For women, chemotherapy can cause an early menopause. You might be able to have hormone replacement therapy to treat the symptoms of a menopause. Ask you doctor about this.

Sometimes women can freeze their eggs or embryos before they start treatment. Talk to your doctor early on if you want to find out more about this. It can take a few weeks and may delay your cancer treatment.

Graft versus host disease

Graft versus host disease (GvHD) is a side effect of transplants from a relative or matched unrelated donor.

GvHD happens because the donor stem cells contain cells from your donor's immune system. These cells sometimes recognise your own tissues as being foreign and attack them. This causes side effects, but can also be an advantage. This is because the immune cells might also attack any lymphoma cells left after your treatment.

GvHD can be acute or chronic.

Acute GvHD starts within 100 days of the transplant. It can cause:

  • diarrhoea
  • weight loss
  • changes in the way your liver works
  • skin rashes

Your doctor will give you drugs called immunosuppressants if you develop GvHD after your transplant. These drugs calm down this immune reaction.

Chronic GvHD starts more than 100 days after the transplant. You might have skin rashes, diarrhoea, sore joints and dry eyes. Your doctor will treat your symptoms with steroids and other drugs. They usually suggest that you stay out of the sun because the sun can make your skin rashes worse.

Life after a transplant

For support and information, you can call the Cancer Research UK information nurses. They can give advice about who can help you and what kind of support is available. Freephone: 0808 800 4040 - Monday to Friday, 9am to 5pm.
Last reviewed: 
04 Jan 2021
Next review due: 
05 Jan 2024
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    National Institute for Health and Care Excellence (NICE), 2016

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    D Engelhard and others
    Transplant Infectious Diseases, 2013. Volume 15, Issue 3

  • Infection-control interventions for cancer patients after chemotherapy: a systematic review and meta-analysis
    A Schlesinger and others
    The Lancet - Infectious Diseases, 2009. Volume 9, Issue 2

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