Doctors use a number of different systems to help them decide which treatment is best for you. One of these is the Barcelona Clinic Liver Cancer (BCLC) staging system. The BCLC looks at all of the following:
- the number and size of tumours in your liver
- your general health and fitness - this is called your performance status or PS
- how well your liver is working (liver function) using a system called the Child-Pugh score
These are all explained below.
Performance status (PS)
Performance status (PS) is a scale to grade how well you are. The BCLC staging system uses the Eastern Cooperative Oncology Group (ECOG) scale:
- PS 0 – you are fully active, more or less as you were before your illness
- PS 1 – you can’t carry out heavy physical work, but can do anything else
- PS 2 – you are up and about more than half the day. You can look after yourself but can’t work
- PS 3 – you are in bed or a chair for more than half the day. You need help to look after yourself
- PS 4 – you are in bed or a chair all the time and need complete care
The Child-Pugh system
The Child-Pugh system looks at the following 5 things that tell how well the liver is working:
- bilirubin levels in the blood
- albumin levels in the blood (albumin is a protein made by the liver)
- how quickly the blood clots (prothrombin time)
- if there is fluid in the abdomen (ascites)
- if the liver disease is affecting brain function (encephalopathy)
Each one is given a number score, and based on that score, people fall into 1 of 3 classes:
- class A means the liver is working normally
- class B means mild to moderate damage
- class C means there is severe liver damage - unfortunately you may be too sick to have treatment for the cancer
The BCLC staging system
There are 5 stages to the BCLC staging system.
Stage 0 (Very early stage)
This means the tumour is less than 2cm, you feel well (PS 0) and your liver is working normally (Child-Pugh A).
Stage A (Early stage)
This means there is a single tumour of any size, or up to 3 tumours all less than 3 cm. You feel well and are active (PS 0), and your liver is working well (Child-Pugh A or B).
Stage B (Intermediate Stage)
This means there are many tumours in the liver, but you feel well (PS 0) and your liver is working well (Child-Pugh A or B).
Stage C (Advanced stage)
This means the cancer has spread into the blood vessels, lymph nodes or other body organs. Or you do not feel well and are less active (PS 1 or 2). Your liver is still working well. (Child-Pugh A or B).
This means you have severe liver damage (Child-Pugh C), or you are not well and need help to look after yourself (PS 3 or 4).
The stage of your cancer helps your doctor to decide which treatment you need. Treatment also depends on:
- where the cancer is
- other health conditions
- your wishes
For cancer that is only in the liver, it might be possible to remove the tumour with surgery. This might be surgery to remove part of your liver (liver resection) or a liver transplant.
You might have a local treatment into your liver if you can't have surgery such as:
- radiofrequency ablation (RFA) or microwave ablation (MWA)
- chemoembolisation (TACE)
- percutaneous ethanal injection (PEI)
- selective internal radiotherapy (SIRT)
For liver cancer that has spread you might have targeted or immunotherapy drugs, such as atezolizumab with bevacuzimab or sorafenib.
If you have severe liver damage, you are usually too unwell to have treatment for your cancer. But your doctor will give you different treatments to help control your symptoms.