A trial looking at MK-3475A and calderasib for advanced non small cell lung cancer that has spread (KANDLELIT 007)

Overview

Cancer types:

Lung cancer, Non small cell lung cancer (NSCLC), Secondary cancers

Status:

Open

Phase:

Phase 3

Details

This trial is comparing MK-3475A and calderasib with MK-3475A and .

It is open to people who:

  • have a type of non small cell lung cancer called non squamous cell

  • are having their first treatment for lung cancer that has spread

  • have a gene change () called KRAS G12C in their lung cancer cells

You pronounce calderasib as kal-dair-ah-sib.

Recruitment start: 13 April 2026

Recruitment end: 7 August 2028

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Ekaterini Boleti

Supported by

Merck Sharp & Dohme Ltd

Last reviewed: 21 May 2026

CRUK internal database number: 20159