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Stages and types of cancer of unknown primary (CUP)

Stages of cancer of unknown primary (CUP)

There is no staging system for cancer of unknown primary (CUP). This is because the cancer has already spread and doctors don’t know where the original cancer started.

Doctors can usually group CUP by the type of cell the cancer started in. 

Find out more about the types of CUP

What is staging?

When someone is diagnosed with cancer, doctors usually carry out a number of tests to find out:

  • the size of the tumour 

  • whether it has spread to other parts of the body

This is called staging. It helps doctors decide on the best treatment plan.

Staging systems

Different cancer types have slightly different staging systems. So the stages used for bowel cancer are different from the stages used for breast cancer, for example.

For most types of cancer there are 4 number stages, from 1 to 4. Stage 1 is a small, localised tumour (early cancer). Cancer that has spread to another part of the body is stage 4 cancer (advanced cancer).

General information about staging

Staging system for CUP

With CUP, doctors don’t know where the original cancer started. So they can't accurately stage this type of cancer.

You usually still have several tests to find out where the cancer is. Your doctor uses all the information they can gather to help decide on your best treatment options.

The results of your scans and tests can often suggest the most likely place the cancer started.

Find out about the different types of tests you might have

Last reviewed: 22 May 2024

Next review due: 22 May 2027

What is cancer of unknown primary (CUP)?

Cancer of unknown primary (CUP) means that cancer spread (secondary cancer) has been found in your body, but doctors don't know where the cancer started (the primary tumour).

Types of cancer of unknown primary

CUP can be grouped according to the type of cell they start from. Doctors can find out which type of cell the cancer started in by looking at a sample of the tumour under the microscope.

Getting diagnosed with CUP

Most people are diagnosed with CUP after they become unwell and go to A&E. Others start by seeing their GP. Find out what to expect when you see a GP and the tests you might have.

Treatment for cancer of unknown primary (CUP)

Treatment for CUP depends on a number of things, including where the cancer is and your general health. You might have a targeted cancer drug or chemotherapy. Sometimes you may have surgery or radiotherapy to help control your symptoms.

Living with CUP

Advice and support is available to help you cope with cancer of unknown primary (CUP) and its treatment.

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