Coronavirus and cancer

We know it’s a worrying time for people with cancer, we have information to help. If you have symptoms of cancer contact your doctor.

Read our information about coronavirus and cancer

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Afatinib (Giotrif)

Afatinib (pronounced aff-a-tin-ib) is a cancer treatment drug and is also known by its brand name Giotrif (pronounced jee-oh-triff).

It is a treatment for lung cancer.

How it works

Aftatinib is a called a cancer growth blocker. It blocks the signals (messages) of particular proteins that tell a cancer to divide and grow. So this can help slow down or stop the cancer growing.

Your doctor will test your cancer cells to see if you can have this drug.

How you have it

Afatinib is a tablet. You swallow it whole with a glass of water.

You can dissolve afatinib in a glass of still water if you have difficulty swallowing tablets. Don’t use any other type of liquid. Drop the tablet into the water without crushing it. Stir it occasionally for up to 15 minutes until the tablet has broken up into very small particles. Drink it straight away. Fill the glass again with water and drink it to make sure you take the whole dose.

Taking your tablets

You must take tablets and capsules according to the instructions your doctor or pharmacist gives you.

Whether you have a full or empty stomach can affect how much of a drug gets into your bloodstream.

You should take the right dose, not more or less.

Talk to your specialist or advice line before you stop taking a cancer drug.

When you have it

You take afatinib once a day on an empty stomach. You take them at least one hour before eating or 3 hours after eating.

You usually carry on taking it for as long as it is still working, unless the side effects get too bad.

Tests

You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

We haven't listed all the side effects. It is very unlikely that you will have all of these side effects, but you might have some of them at the same time.

How often and how severe the side effects are can vary from person to person. They also depend on what other treatment you are having. For example, your side effects could be worse if you are also having other drugs or radiotherapy.

When to contact your team

Your doctor or nurse will go through the possible side effects. They will monitor you closely during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:

  • you have severe side effects 
  • your side effects aren’t getting any better
  • your side effects are getting worse
Early treatment can help manage side effects better.

Common side effects

Each of these effects happens in more than 10 out 100 people (10%). You might have one or more of them. They include:

Diarrhoea 

Contact your advice line if you have diarrhoea, such as if you've had 4 or more loose watery poos (stools) in 24 hours. Or if you can't drink to replace the lost fluid. Or if it carries on for more than 3 days.

Your doctor may give you anti diarrhoea medicine to take home with you after treatment. Eat less fibre, avoid raw fruits, fruit juice, cereals and vegetables, and drink plenty to replace the fluid lost.

Skin changes 

Skin problems include a skin rash, dry skin and itching. This usually goes back to normal when your treatment finishes. Your nurse will tell you what products you can use on your skin to help.

Sore mouth

Mouth sores and ulcers can be painful. Keep your mouth and teeth clean; drink plenty of fluids; avoid acidic foods such as oranges, lemons and grapefruits; chew gum to keep the mouth moist and tell your doctor or nurse if you have ulcers.

Swelling around nails (Paronychia)

 The skin around your nail might get swollen, red, and sore. It may also become infected. Talk to the team looking after you if you notice this. 

Loss of appetite

You might lose your appetite for various reasons when you are having cancer treatment. Sickness, taste changes or tiredness can put you off food and drinks.

Feeling or being sick

Feeling or being sick is usually well controlled with anti sickness medicines. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniques, can all help.

It is important to take anti sickness medicines as prescribed even if you don’t feel sick. It is easier to prevent sickness rather than treating it once it has started.

Nosebleeds

Talk to the team looking after you about this.

Occasional side effcets

Each of these effects happens in between 1 and 10 out of 100 people (1 and 10%). You might have one or more of them. They include:

  • eye problems such as dry, watery, gritty or itchy eyes
  • redness and peeling on the hands and feet
  • liver changes - these usually do not cause any symptoms and you have regular blood tests to check this
  • soreness and inflammation of the bladder
  • kidney changes
  • taste changes
  • indigestion
  • swollen lips
  • high temperature (fever)
  • weight loss
  • runny nose
  • muscle cramps
  • nail changes
  • change in mineral levels in the blood
  • loss of body fluid (dehydration)

Rare side effects

These effects happens in fewer than 1 out of 100 people (1%). They include:

  • inflammation and scarring of the lung tissue – let your team know if you develop shortness of breath, cough or high temperature
  • inflammation of the pancreas (symptoms include severe tummy pain, feeling or being sick, a high temperature or you may have loose poo)
  • inflammation of the clear front layer of the eye (cornea) – symptoms might include pain, sensitivity to light, blurred vision, and redness
  • a hole in the bowel wall (perforation)
  • a severe skin reaction that may start as tender red patches which leads to peeling or blistering of the skin. You might also feel feverish and your eyes may be more sensitive to light. This is serious and could be life threatening

Coping with side effects

We have more information about side effects and tips on how to cope with them.

What else do I need to know?

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Lactose intolerance

This drug contains lactose (milk sugar). If you have an intolerance to lactose, contact your doctor before taking this medicine.

Pregnancy and contraception

This drug may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug and for at least a month afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.

Fertility

It is not known whether this treatment affects fertility in people. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.

Breastfeeding

Don’t breastfeed during this treatment because the drug may come through into your breast milk.

Treatment for other conditions

Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Immunisations

Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and the shingles vaccine (Zostavax).

You can:

  • have other vaccines, but they might not give you as much protection as usual
  • have the flu vaccine (as an injection)

Contact with others who have had immunisations - You can be in contact with other people who have had live vaccines as injections. Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as the oral typhoid vaccine.

If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray. This is for 2 weeks following their vaccination.

Babies have the live rotavirus vaccine. The virus is in the baby’s poo for about 2 weeks and could make you ill if your immunity is low. Get someone else to change their nappies during this time if you can. If this isn't possible, wash your hands well after changing their nappy.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help