Mesothelioma incidence statistics

Cases

New cases of mesothelioma, 2013, UK

 

Proportion of all cases

Percentage mesothelioma is of total cancer cases, 2013, UK

 

Age

Age that almost half of mesothelioma cases are diagnosed, 2011-2013, UK

 

Trend since 1970s

Mesothelioma incidence rates have increased since the late 1970s, GB

 

Mesothelioma accounts for 0.8% of all cancers in the UK (2013). In males, it is the 17th most common cancer in the UK (accounting for 1% of all male cases). In females, it accounts for 0.3% of all female cases.[1-4]

In 2013, there were 2,667 new cases of mesothelioma in the UK: 2,222 (83%) in males and 445 (17%) in females, giving a male:female ratio of around 50:10.[1-4] The crude incidence rate Open a glossary item shows that there are 7 new mesothelioma cases for every 100,000 males in the UK, and 1 for every 100,000 females.

The marked male excess in mesothelioma incidence reflects sex differences in occupational asbestos exposure.[5]

The European age-standardised incidence rates Open a glossary item (AS rates) are significantly higher for females in England compared with Northern Ireland. Rates do not differ significantly between the other constituent countries of the UK for either sex.[1-4]

Mesothelioma (C45), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2013

England Wales Scotland Northern Ireland UK
Male Cases 1,879 116 188 39 2,222
Crude Rate 7.1 7.7 7.3 4.3 7.0
AS Rate 8.9 8.5 9.1 6.6 8.8
AS Rate - 95% LCL 8.5 7.0 7.8 4.6 8.4
AS Rate - 95% UCL 9.3 10.1 10.5 8.7 9.2
Female Cases 387 17 37 4 445
Crude Rate 1.4 1.1 1.3 0.4 1.4
AS Rate 1.5 1.0 1.4 0.5 1.4
AS Rate - 95% LCL 1.3 0.5 0.9 0.0 1.3
AS Rate - 95% UCL 1.6 1.5 1.8 1.0 1.6
Persons Cases 2,266 133 225 43 2,667
Crude Rate 4.2 4.3 4.2 2.4 4.2
AS Rate 4.8 4.3 4.6 3.0 4.7
AS Rate - 95% LCL 4.6 3.6 4.0 2.1 4.5
AS Rate - 95% UCL 5.0 5.1 5.3 3.9 4.9

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS rate Open a glossary item

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Mesothelioma incidence rates throughout the UK vary moderately between the former cancer networks.[5] Within England, in males, the highest rates are in parts of the south, south-east and north of England.[6] This geographical variation reflects the location of industries involving asbestos exposure.[6]

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp#605
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=590805626
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
  5. Mesothelioma (C) European age standardised incidence rates by UK Cancer Networks, 2008-2010. These data were extracted from the UK Cancer Information Service, version 4.5b 001 on 30/01/2014. 
  6. National Cancer Intelligence Network (NCIN). Malignant Pleural Mesothelioma NCIN Data Briefing. NCIN: London; 2012. 
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Mesothelioma incidence is strongly related to age, with the highest incidence rates being in older people. In the UK in 2011-2013, on average each year almost half (48%) of cases were diagnosed in people aged 75 and over.[1-4]

Age-specific incidence rates rise steeply in males and gradually in females from around age 50-54, peaking in the 80-84 age group for males and in the 75-79 age group for females, and subsequently dropping. Incidence rates are higher for males than females aged 45-49 and over (this gap is not significant at younger ages), and this gap is widest at age 90+, when the male:female incidence ratio of age-specific rates (to account for the different proportions of males to females in each age group) is around 89:10.[1-4]

Mesothelioma (C45), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2011-2013

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp#605
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=590805626
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
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Mesothelioma incidence rates have increased by 497% in Great Britain since the late 1970s.[1-3] This includes a slightly larger increase for males than for females.

For males, European age-standardised (AS) Open a glossary item incidence rates increased almost six-fold (498% increase) between 1979-1981 and 2011-2013. The rise is smaller for females, with rates increasing more than five-fold (434% increase) between 1979-1981 and 2011-2013. For males, most of the increase occurred before the early 2000s, and in females this has been a steady increase.

Mesothelioma (C45), European Age-Standardised Incidence Rates, by Sex, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Over the last decade in the UK (between 2002-2004 and 2011-2013), mesothelioma AS incidence rates have increased by 11% for males and females combines, which includes a larger increase in females (22%) than males (8%).[1-4]

Mesothelioma (C45), European Age-Standardised Incidence Rates, by Sex, UK, 1993-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Mesothelioma incidence trends probably reflect changing prevalence of risk factors, with recent incidence trends influenced by risk factor prevalence in years past. Trends by age group reflect risk factor exposure in birth cohorts.

Mesothelioma incidence rates in Great Britain have overall increased for most of the broad age groups since the late 1970s.[1-3] The largest increases have been in people aged 80 and over, with European AS incidence rates increasing more than 22-fold (2111% increase) between 1979-1981 and 2011-2013, and in people aged 70-79 with rates increasing by more than 10-fold (924% increase). The rates in 60-69 year-olds increased from the late 1970s and reached a peak in 2005-2007 (431% increase between 1979-81 and 2005-2007), but have since decreased (18% decrease between 2005-2007 and 2011-2013). Rates in those aged 50-59 almost tripled (195% increase) between 1979-1981 and 1998-2000, but decreased thereafter (by 59% between 1998-2000 and 2011-2013).

Mesothelioma (C45), European Age-Standardised Incidence Rates, by Age, Persons, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp#605
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=590805626
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
Last reviewed:

Most mesothelioma cases occur in the pleura Open a glossary item, with much smaller proportions in the peritoneum Open a glossary item and pericardium Open a glossary item (2010-2012).[1-4] This reflects that asbestos typically enters the body via inhalation, rather than ingestion.[5]

The proportion of cases in each part is similar between males and females.[1-4]

A small proportion of cases did not have the specific site of the mesothelioma recorded in cancer registry data, or overlapped more than one part.[1-4]

Mesothelioma (C45), Percentage Distribution of Cases Diagnosed By Anatomical Site, UK, 2010-2012

Cases and percentages may not sum due to rounding

References

  1. Data were provided by the Office for National Statistics on request, July 2014. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2014. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, April 2014. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, June 2014. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/CancerInformation/.
  5. Robinson BW, Musk AW, Lake RA. Malignant mesothelioma. Lancet 2005;366(9483):397-408.
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The lifetime risk of developing mesothelioma is around 1 in 140 for men and around 1 in 710 for women, in 2012 in the UK.[1]

The lifetime risk for mesothelioma has been calculated on the assumption that the possibility of having more than one diagnosis of mesothelioma over the course of a lifetime is very low (‘Current Probability’ method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Esteve J, Benhamou E and Raymond L. Descriptive epidemiology. IARC Scientific Publications No.128, Lyon, International Agency for Research on Cancer, pp 67-68 1994.
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There is no evidence for an association between mesothelioma incidence and deprivation for either males or females in England.[1] England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are similar for both males and females living in the most deprived areas compared with the least deprived.[1]

Mesothelioma (C45), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in mesothelioma incidence between people living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

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In the UK around 2,100 people were still alive at the end of 2006, up to ten years after being diagnosed with mesothelioma.[1]

Mesothelioma (C45), One, Five and Ten Year Cancer Prevalence, UK, 31st December 2006

1 Year Prevalence 5 Year Prevalence 10 Year Prevalence
Male 992 1,547 1,651
Female 218 366 404
Persons 1,210 1,913 2,055

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Few attempts have been made to quantify the global incidence of mesothelioma, mainly because it is a comparatively rare cancer and is not reported in many developing countries worldwide[1]; consequently, mesothelioma is not included in the cancer incidence and mortality worldwide database published by the International Agency for Research on Cancer.[2] However, using a combination of mortality data and information on asbestos use to predict incidence, one research group estimates that an average of 14,200 mesothelioma cases are diagnosed worldwide each year (using 1994-2008 data and assuming no increase in incidence during that time).[3] According to these estimates, the UK has the second highest number of cases in the world, next to the United States.

An analysis of the most common type of mesothelioma, pleural mesothelioma, in Europe in the 1990s shows that Scotland and England were estimated to have the highest European AS incidence rates in 40-74 year-olds; and while the increase in incidence slowed down or remained static in most European countries between the late 1980s and mid-1990s, the rates continued to increase significantly in England and France.[4]

Asbestos production and use continues in many parts of the world, with Russia and China the main exporters.[5]

References

  1. Park EK, Takahashi K, Hoshuyama T, et al. Global magnitude of reported and unreported mesothelioma. Environ Health Perspect 2011;119:514-8.
  2. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan.iarc.fr. Accessed May 2011. 
  3. Hodgson JT, McElvenny DM, Darnton AJ, et al. The expected burden of mesothelioma mortality in Great Britain from 2002 to 2050. Br J Cancer 2005;92(3):587-93. 
  4. Montanaro F, Bray F, Gennaro V, et al. Pleural mesothelioma incidence in Europe: evidence of some deceleration in the increasing trends. Cancer Causes Control 2003;14:791-803. 
  5. US Geological Survey. Asbestos Statistics and Information. Available from: http://minerals.usgs.gov/minerals/pubs/commodity/asbestos/. Accessed December 2013. 
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