Early Detection OHSU Project Award

About this scheme

Key information

Career level
Early career researcher
Mid-career researcher
Established independent researcher
Non-clinical researcher
Clinician
Research area
Biomarker research
Clinical trials
Pre-clinical research
Imaging research
Statistics and methodology
Cancer biology
Final submission
Committee review
Funding period
Up to 2 years
Funding amount
Up to £250,000 plus $300,000 for OHSU-based researchers
Funds new and existing collaborations in early detection between researchers in the UK and at Oregon Health and Sciences University (OHSU).

Each application must have a lead applicant from both a UK institution and OHSU.

You should:

  • Have at least three years’ postdoctoral experience or equivalent
  • Be scientists, clinicians or healthcare workers in UK universities, medical schools, hospitals, CRUK Institutes or other research institutions, or at OHSU

Scientific remit

Early detection (EDx) research seeks to identify cancer or pre-cancerous states at the earliest possible point at which an intervention might be made. such signals will detect, but may also underpin prognosis/stratification/prediction of response to therapy and prevention. EDx projects will support discovery and translational/clinical research which is mindful of the clinical and population context.

We know that the chances of survival increase significantly for almost all patient groups if cancer is detected and treated at an early stage. EDx research offers the potential for transformational improvements in patient outcomes and will be essential in making progress towards our vision of 3 in 4 patients surviving the disease by 2034.

EDx operates across the full pathway of disease development: detecting events from the earliest changes suggesting initiation, to dysregulated growth, promotion to pre-neoplastic states/lesions, malignant conversion, and tumour progression. Each of these stages provide an opportunity to detect a shift in state, and ultimately to intervene to improve survival. Early detection can also be applied post-therapy, to detect recurrence at the earliest possible point.

The remit of these awards includes:

  • Biological research underpinning early detection and biomarker discovery and validation
  • Human-based EDx discovery research
  • Epidemiology and risk stratification for EDx (to inform populations for targeted research or screening)
  • Data and computation-driven approaches to EDx
  • Development and utilization of preclinical EDx model systems
  • EDx technology development
  • Translational and clinical EDx research

For additional detail, read the Application Guidelines (PDF).

Your project may focus on any of these research areas, or any combination of them. Your proposal should consider line-of-sight to clinical or population impact.  

EDx projects will drive transatlantic collaboration and facilitate early detection knowledge exchange. We want to bring together outstanding teams to further establish a research community around this nascent field.

Find a collaborator

Looking for a collaborator for this award?

Submit your details and search for a potential partner using our Early Detection Collaboration Matcher.

Awarded once annually and are typically made up to £250K for UK-based researchers plus $300,000 for OHSU-based researchers for up to 2 years, and may be used to fund:

  • Postdoctoral researchers
  • Technical staff
  • Associated running expenses
  • Equipment up to £5,000/$5,000

How to apply to this scheme

Overview of the application process

  1. You must contact the Early Detection Team to open an application for this scheme. You also have the option for an informal and confidential discussion of your proposal. We will advise you on eligibility and funding options (this is not compulsory, but it is recommended).
  2. Submit an application, which will be peer-reviewed by experts. You will have the opportunity to respond to reviewers’ comments.
  3. Your application will be considered by the Early Detection Research Committee

.All applications must be made online through our online grant management system  eGMS, and your final application must be approved online by your host institution.

Timelines

Deadline: 16 January 2018

Committee Review: June 2018

Before you begin your application

Whichever stage of research the proposal addresses, from discovery to applied, proposals should have a clear line-of-sight to clinical/population impact, and should articulate this pathway and the evidence that will be required to advance along it.  Implementation of this clinical line of sight may be either during or downstream of the proposed work (it is not mandatory for all proposals to include a direct translational component).  Appropriate involvement of clinical/population expertise to ensure this line-of-sight is encouraged.

While therapeutic development is not covered by the EDx programme (being funded through other CRUK mechanisms), EDx research should acknowledge and account for the importance of therapeutics as context, and to help inform understanding of when surveillance is more appropriate than intervention.

Teams of applicants should be assembled to adequately consider these issues, involving collaboration between e.g. biologists, clinical researchers, engineers/physical scientists, maths/stats/computation expertise, population scientists and industry (as appropriate to the proposal).  Multidisciplinary, overseas and industrial collaboration is encouraged when appropriate to the science proposed, and where clear added value can be articulated.

Applicants are encouraged to make use of existing cohorts and tissue banks as resources for EDx research.

Applications will be judged based on:

  • Scientific excellence and innovation
  • Clear articulation of the challenge to be addressed
  • Cancer early detection relevance
  • Clarity of line-of-sight to clinical/population impact
  • Team composition: are the requisite skillsets to deliver the proposed work and achieve impact in place? Do any collaborations between disciplines, institutions or with industry add value to the project?
  • Is the required infrastructure in place to deliver the proposed research?

Cancer Research UK contact details

Dr Alexis Webb

Dr Alexis Webb

Senior Research Funding Manager

earlydetection@cancer.org.uk

Tel: +44 (0) 20 3469 5232

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