New Agents Committee

The New Agents Committee (NAC) selects new anti-cancer treatments for early clinical trials.

NAC members are expert in early clinical trials of novel agents and other aspects of drug development. Proposals and meetings are confidential. NAC-approved novel agents in development include: molecularly targeted small molecules, cytotoxic agents, antibodies, vaccines, viral gene therapy, immunotherapy, cell therapy, radioimmunotherapy, diagnostics and imaging agents.

Research areas

The NAC is interested in proposals for scientifically-driven trials of novel unregistered anti-cancer agents. NAC reviews and funds:

  • Exploratory/preclinical development prior to a clinical trial
  • Phase 1 trials, including first-in-man and first-in-class
  • Combinations trials of unregistered and registered agents
  • Early phase 2 hypothesis-testing trials

How proposals are judged

Proposals are subject to external, international peer review and are judged on the basis of:

  • Scientific rationale and importance
  • Uniqueness/novelty of the target or agent
  • Significance of the proposed trial and its endpoints
  • Clinical need
  • Quality of data in relevant models
 

Committee chairs and members

Chair of the New Agents Committee

Professor Ruth Plummer - Northern Institute for Cancer Research, Newcastle

Vice-Chair of the New Agents Committee

Professor Andrew Hughes – University of Manchester (Acting vice-chair)

NAC members

Professor Fran Balkwill – Queen Mary, University of London

Dr Sarah Blagden – University of Oxford

Professor Neil Carragher –University of Edinburgh

Professor John Chester – University of Cardiff School of Medicine

Dr Mark Cobbold – Harvard University

Dr Andrew Davies – School of Medicine, University of Southampton

Professor Michelle Garrett – University of Kent

Professor Linda Hakes – Independent /Royal Pharmaceutical Society

Professor Margaret Harnett - University of Glasgow

Professor Andrew Hughes – University of Manchester

Mr Bo Kara – GlaxoSmithKline

Professor Pam Kearns – CCLG & University of Birmingham

Professor Richard Kennedy – Queen’s University Belfast

Professor Alan Melcher – Institute of Cancer Research

Dr Paul Mulholland – University College London Hospitals

Dr Klaus Okkenhaug – Babraham Institute

Dr Olivia Rossanese – The Institute of Cancer Research

Professor Manuel Salto-Tellez – Queen’s University Belfast

Professor Ricky Sharma – University College London

Professor James Spicer – King's College London

Professor Will Steward – University of Leicester

Dr Fiona Thomson - University of Glasgow

Professor Dr Jaap Verweij – Erasmus University Rotterdam

Professor Steve Wedge – University of Newcastle

Chairs of the Exploratory Research Panel

Professor Neil Carragher –University of Edinburgh

Professor Michelle Garrett – University of Kent

Exploratory Research Panel members

Professor Fran Balkwill – Queen Mary, University of London

Dr Mark Cobbold – Harvard University

Professor Linda Hakes – Independent /Royal Pharmaceutical Society

Professor Margaret Harnett - University of Glasgow

Professor Andrew Hughes – University of Manchester

Professor Richard Kennedy – Queen’s University Belfast

Professor Alan Melcher – Institute of Cancer Research

Dr Klaus Okkenhaug – Babraham Institute

Professor Ruth Plummer – Northern Institute for Cancer Research, Newcastle

Dr Olivia Rossanese – The Institute of Cancer Research

Professor Ricky Sharma – University College London

Dr Fiona Thomson - University of Glasgow

Professor Steve Wedge – University of Newcastle

Chair of the Translational Research Panel

Professor Ruth Plummer – Northern Institute for Cancer Research, Newcastle

Vice-chair of the Translational Research Panel

TBC

Translational Research Panel members

Dr Sarah Blagden – University of Oxford

Professor Neil Carragher – University of Edinburgh

Professor John Chester – University of Cardiff School of Medicine

Dr Andrew Davies – School of Medicine, University of Southampton

Professor Michelle Garrett – University of Kent

Mr Bo Kara – GlaxoSmithKline

Professor Pam Kearns – CCLG & University of Birmingham

Dr Paul Mulholland – University College London Hospitals

Professor Manuel Salto-Tellez – Queen’s University Belfast

Professor James Spicer – King's College London

Professor Will Steward – University of Leicester

Professor Dr Jaap Verweij – Erasmus University Rotterdam

Contact for this committee

Kate Searle

Kate Searle

Research Funding Manager

Kate.Searle@cancer.org.uk

Tel: +44 (0) 20 3469 6929

Schemes reviewed by this committee

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Clinical Research Committee

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