A study to find out more about why people respond to chemotherapy differently

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

All cancer types





This study is aiming to find out more about how people respond to chemotherapy by looking at blood samples of people having platinum chemotherapy drugs at Leicester Royal Infirmary.

Doctors often use chemotherapy to treat cancer. Chemotherapy drugs are grouped according to how they work. Platinum chemotherapy includes cisplatin, oxaliplatin and carboplatin. They work by reacting with the DNA of the cancer cell, making it die. Platinum chemotherapy treats a wide range of cancers. But it doesn’t always help everybody. Doctors don’t want to put people through long courses of treatment and side effects if it won’t help them. But they can’t always tell in advance how well it will work.

Researchers will look at DNA taken from blood samples to see whether one of the genes involved in repairing damage from platinum chemotherapy predicts how well people respond to treatment. They hope in future that this information may help them develop a blood test to predict how people would respond to platinum treatment. The aim of this study is to find out why some people respond better to platinum chemotherapy than others.

You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.

Who can enter

You can enter this study if you

  • Have cancer that has spread to another part of your body (metastasised)
  • Are having, or waiting to start, your first course of chemotherapy, and this contains a platinum drug, for example cisplatin, oxaliplatin or carboplatin
  • Are at least 18 years of age

Trial design

This study will recruit 75 people having platinum chemotherapy Open a glossary item  at the Leicester Royal Infirmary. Everyone taking part will give a series of blood samples throughout their course of chemotherapy Open a glossary item.  

You will also give permission for the study team to gather further information about your cancer from your medical notes.

Hospital visits

You will give 2 blood samples on the same day as you have chemotherapy. If needed, you will also give a blood sample

  • One day after your chemotherapy
  • One week after your chemotherapy

You will do this for your first, middle and last cycles of treatment.

So you may need to make up to 6 extra hospital visits on days you do not have chemotherapy. If you cannot do this, a member of the study team may be able to come to your home to collect these samples.

Side effects

You may have a small bruise where you had blood taken.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr A. L. Thomas

Supported by

Da Vinci Health Technology Innovation Network
Experimental Cancer Medicine Centre (ECMC)
Healthcare and Bioscience iNet
Hope against cancer
University Hospitals of Leicester NHS Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 4572

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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