"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
A study to find out more about why people respond to chemotherapy differently
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is aiming to find out more about how people respond to chemotherapy by looking at blood samples of people having platinum chemotherapy drugs at Leicester Royal Infirmary.
Doctors often use chemotherapy to treat cancer. Chemotherapy drugs are grouped according to how they work. Platinum chemotherapy includes cisplatin, oxaliplatin and carboplatin. They work by reacting with the DNA of the cancer cell, making it die. Platinum chemotherapy treats a wide range of cancers. But it doesn’t always help everybody. Doctors don’t want to put people through long courses of treatment and side effects if it won’t help them. But they can’t always tell in advance how well it will work.
Researchers will look at DNA taken from blood samples to see whether one of the genes involved in repairing damage from platinum chemotherapy predicts how well people respond to treatment. They hope in future that this information may help them develop a blood test to predict how people would respond to platinum treatment. The aim of this study is to find out why some people respond better to platinum chemotherapy than others.
You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.
Who can enter
This study will recruit 75 people having
You will also give permission for the study team to gather further information about your cancer from your medical notes.
You will give 2 blood samples on the same day as you have chemotherapy. If needed, you will also give a blood sample
- One day after your chemotherapy
- One week after your chemotherapy
You will do this for your first, middle and last cycles of treatment.
So you may need to make up to 6 extra hospital visits on days you do not have chemotherapy. If you cannot do this, a member of the study team may be able to come to your home to collect these samples.
You may have a small bruise where you had blood taken.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr A. L. Thomas
Da Vinci Health Technology Innovation Network
Experimental Cancer Medicine Centre (ECMC)
Healthcare and Bioscience iNet
Hope against cancer
University Hospitals of Leicester NHS Trust