A trial looking at gemcitabine and cisplatin for advanced bladder cancer

Cancer type:

Bladder cancer
Transitional cell cancer




Phase 2

This trial looked at gemcitabine and cisplatin chemotherapy for bladder cancer that had come back after treatment or spread to another part of the body.

Cisplatin was already being used for advanced bladder cancer, but it does cause side effects. Gemcitabine was a newer drug and appeared to cause fewer side effects.

The aims of the trial were to find out

  • The best dose of gemcitabine and cisplatin to use
  • More about the side effects
  • How well this combination worked for advanced bladder cancer

Summary of results

The research team found that the combination of gemcitabine and cisplatin chemotherapy is useful for treating advanced bladder cancer.

This trial recruited 32 patients aged 41 to 79 with advanced bladder cancer.

  • In 4 people the cancer went away - researchers call this ‘complete response
  • In 17 people the cancer slowed or stopped growing - researchers call this ‘partial response
  • In 6 people the cancer remained the same - researchers call this ‘stable disease
  • 1 person’s cancer continued to grow
  • They did not have results for 4 people

The most common side effect was a drop in blood cell counts.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Nick James

Supported by

University of Birmingham

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 169

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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